The etiology of neural tube defects: the role of folic acid

被引：8
|
作者：
McLone, DG [1 ]
机构：
[1] Childrens Mem Hosp, Div Neurol Surg, Chicago, IL 60614 USA
来源：
CHILDS NERVOUS SYSTEM | 2003年 / 19卷 / 7-8期
关键词：
folic acid; neural tube defects; spina bifida;
D O I：
10.1007/s00381-003-0793-2
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Discussion: While the cause of neural tube defects in humans is considered to be multifactorial, it is apparent that folic acid can prevent 70% of open neural tube defects. Even in laboratory animals with known genetic defects, folic acid can prevent the genetic expression. Conclusion: While some of the metabolic pathways for folic acid are known, the true effects of folic acid on closure of the neural tube have yet to be discovered.
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页码：537 / 539
页数：3
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