Nivolumab-Related Dry Mouth and Dry Eye: Cross-Sectional Study

被引：4

作者：

Yildirim, Ozgen Ahmet ^{[1
]}

Poyraz, Kerem ^{[2
]}

Erdur, Erkan ^{[1
]}

Can, Canan ^{[3
]}

Gundogan, Cihan ^{[3
]}

Guzel, Yunus ^{[3
]}

Etem, Hulya ^{[4
]}

Komek, Halil ^{[3
]}

机构：

[1] Gazi Yasargil Training & Res Hosp, Div Med Oncol, Dept Internal Med, TR-21010 Diyarbakir, Turkey

[2] Gazi Yasargil Training & Res Hosp, Dept Radiat Oncol, Diyarbakir, Turkey

[3] Gazi Yasargil Training & Res Hosp, Dept Nucl Med, Diyarbakir, Turkey

[4] Gazi Yasargil Training & Res Hosp, Dept Pathol, Diyarbakir, Turkey

来源：

CANCER INVESTIGATION | 2021年 / 39卷 / 10期

关键词：

Reduced tear production; Nivolumab; Schirmer's; SJOGRENS-SYNDROME; TOXICITIES; PEMBROLIZUMAB; ANTI-PD-1;

D O I：

10.1080/07357907.2021.1971241

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To evaluate ICIs related dry eye and dry mouth in nivolumab therapy, 24 patients receiving nivolumab (group 1), 30 patients in remission without treatment for 6 months (group 2), 30 healthy participants (group 3) were cross-sectionally examined. Schirmer's 1, 2, TSH blood tests, serological analysis, salivary flow scintigraphy and minor-salivary gland biopsy were performed. Schirmer's tests were performed with anesthetic (1) and without anesthetic (2). Schirmer's scores were lower in group 1 with more frequent reduced tear production (p < 0.001). TSH levels negatively correlated with Schirmer's scores. Functional insufficiency was detected by salivary flow scintigraphy in 7 out of 10 patients with Schirmer's test positivity. In Schirmer's positive patients, lymphocytic sialadenitis was confirmed in 4 patients (focus score > 1) and CD4 T lymphocyte precipitation was observed in 6 patients. Nivolumab therapy may be associated with ICIs related immune sicca.

引用

页码：797 / 807

页数：11

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