Alkenylation and Arylation of Peptides via Ni-Catalyzed Reductive Coupling of α-C-Tosyl Peptides with Csp2 Triflates/Halides

被引：7
作者：
Tao, Xianghua [1 ]
Ma, Guobin [1 ]
Song, Yanhong [1 ]
Chen, Yunrong [2 ]
Qian, Qun [1 ]
Sun, Deli [1 ]
Gong, Hegui [1 ]
机构：
[1] Shanghai Univ, Ctr Supramol Chem & Catalysis, Sch Mat Sci & Engn, Dept Chem, Shanghai 200444, Peoples R China
[2] ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 19期
关键词：
AMINO-ACIDS; FUNCTIONALIZATION; SULFONES; HALIDES; PHOTOREDOX;
D O I：
10.1021/acs.orglett.1c02601
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Ni-catalyzed reductive cross-coupling between alpha-C-tosyl peptides and Csp(2) triflates/halides has been developed. This protocol enables the formation of various unnatural di- and tripeptides containing vinyl and aryl side chains, and it expands the applications of Ni-catalyzed reductive cross-coupling in late-stage diversification of peptides.
引用
收藏
页码：7418 / 7422
页数：5
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