Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment

被引：6

作者：

Ta, Robert ^{[1
]}

Yang, David ^{[2
]}

Hirt, Christian ^{[2
]}

Drago, Thomas ^{[3
,4
]}

Flavin, Richard ^{[3
,4
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02114 USA

[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[3] St James Hosp, Dept Histopathol, Dublin D08 NHY1, Ireland

[4] Trinity Coll Dublin, Dublin DO8 NHY1, Ireland

来源：

DIAGNOSTICS | 2022年 / 12卷 / 05期

关键词：

molecular; diagnostics; diffuse large B-cell lymphoma; cell-of-origin; immunohistochemistry; gene expression profiling; cytogenetics; FISH; minimum criteria for diagnosis; RITUXIMAB PLUS CYCLOPHOSPHAMIDE; GENE-EXPRESSION; RISK STRATIFICATION; MYC REARRANGEMENT; R-CHOP; CLASSIFICATION; DOXORUBICIN; VINCRISTINE; SURVIVAL; IBRUTINIB;

D O I：

10.3390/diagnostics12051087

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. It is a clinically and morphologically heterogeneous entity that has continued to resist complete subtyping. Molecular subtyping efforts emerged in earnest with the advent of gene expression profiling (GEP). This molecular subtyping approach has continued to evolve simultaneously with others including immunohistochemistry and more modern genomic approaches. Recently, the veritable explosion of genomic data availability and evolving computational methodologies have provided additional avenues, by which further understanding and subclassification of DBLCLs is possible. The goal of this review is to provide a historical overview of the major classification timepoints in the molecular subtyping of DLBCL, from gene expression profiling to present day understanding.

引用

页数：16

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