The distinct roles of exosomes in tumor-stroma crosstalk within gastric tumor microenvironment

被引：20

作者：

Zhang, Hanyu ^{[1
,2
]}

Yang, Min ^{[1
,3
]}

Wu, Xu ^{[1
,3
]}

Li, Qianxiu ^{[4
]}

Li, Xin ^{[1
,3
]}

Zhao, Yueshui ^{[1
,3
]}

Du, Fukuan ^{[1
,3
]}

Chen, Yu ^{[1
,3
]}

Wu, Zhigui ^{[5
]}

Xiao, Zhangang ^{[1
,3
]}

Shen, Jing ^{[1
,3
]}

Wen, Qinglian ^{[6
]}

Hu, Wei ^{[7
]}

Cho, Chi Hin ^{[1
,3
,8
]}

Chen, Meijuan ^{[1
]}

Zhou, Yejiang ^{[4
]}

Li, Mingxing ^{[1
,3
]}

机构：

[1] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou 646000, Sichuan, Peoples R China

[2] Nanchong Cent Hosp, Clin Med Coll 2, North Sichuan Med Coll, Dept Pharm,Nanchong Key Lab Individualized Drug T, Nanchong 637000, Sichuan, Peoples R China

[3] South Sichuan Inst Translat Med, Luzhou 646000, Sichuan, Peoples R China

[4] Southwest Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp, Luzhou 646000, Sichuan, Peoples R China

[5] Southwest Med Univ, Dept Pharm, Affiliated Hosp, Luzhou 646000, Sichuan, Peoples R China

[6] Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 646000, Sichuan, Peoples R China

[7] Southern Med Univ, Shenzhen Hosp, Dept Gastroenterol, Shenzhen 518000, Peoples R China

[8] Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China

来源：

PHARMACOLOGICAL RESEARCH | 2021年 / 171卷

基金：

中国国家自然科学基金;

关键词：

Exosome; Tumor microenvironment; Tumor-stroma crosstalk; Biomarker; Gastric cancer; CANCER-ASSOCIATED FIBROBLASTS; MESENCHYMAL STEM-CELLS; DIAGNOSTIC BIOMARKER; NONCODING RNAS; DOXORUBICIN RESISTANCE; EXTRACELLULAR-MATRIX; POTENTIAL BIOMARKER; MEDIATED TRANSFER; PROMOTES; INVASION;

D O I：

10.1016/j.phrs.2021.105785

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gastric cancer (GC) development is a complex process displaying polytropic cell and molecular landscape within gastric tumor microenvironment (TME). Stromal cells in TME, including fibroblasts, endothelial cells, mesenchymal stem cells, and various immune cells, support tumor growth, metastasis, and recurrence, functioning as the soil for gastric tumorigenesis. Importantly, exosomes secreted by either stromal cells or tumor cells during tumor-stroma crosstalk perform as crucial transporter of agents including RNAs and proteins for cell-cell communication in GC pathogenesis. Therefore, given the distinct roles of exosomes secreted by various cell types in GC TME, increasing evidence has indicated that exosomes present as new biomarkers for GC diagnosis and prognosis and shed light on novel approaches for GC treatment.

引用

页数：17

共 195 条

[1] The tumorigenic and therapeutic functions of exosomes in colorectal cancer: Opportunity and challenges [J].