Serotonergic Control of Metabolic Homeostasis

被引：54
作者：
Wyler, Steven C. [1 ]
Lord, Caleb C. [1 ]
Lee, Syann [1 ]
Elmquist, Joel K. [1 ,2 ]
Liu, Chen [1 ,3 ]
机构：
[1] UT Southwestern Med Ctr, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA
[2] UT Southwestern Med Ctr, Dept Pharmacol, Dallas, TX USA
[3] UT Southwestern Med Ctr, Dept Neurosci, Dallas, TX 75390 USA
来源：
FRONTIERS IN CELLULAR NEUROSCIENCE | 2017年 / 11卷
关键词：
serotonin; obesity; diabetes; feeding; gluconeogenesis; adipose tissue; pancreas; BROWN ADIPOSE-TISSUE; 5-HT2C RECEPTOR AGONIST; INTRAVENTRICULAR PARA-CHLOROPHENYLALANINE; NEURONS REGULATE ENERGY; PANCREATIC BETA-CELL; INDUCED WEIGHT-GAIN; REDUCES FOOD-INTAKE; PROOPIOMELANOCORTIN NEURONS; PERIPHERAL SEROTONIN; INSULIN-SECRETION;
D O I：
10.3389/fncel.2017.00277
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This review aims to synthesize pharmacological and genetic studies that have found diverse functions of both central and peripheral 5-HT in the control of food intake, thermogenesis, and glucose and lipid metabolism. We also discuss the potential benefits of targeting the 5-HT system to combat metabolic disease.
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页数：9
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