Antisperm antibodies and conception

被引：83
作者：
Chamley, L. W. [1 ]
Clarke, G. N.
机构：
[1] Univ Auckland, Dept Obstet & Gynaecol, Auckland 1, New Zealand
[2] Greenlane Clin Ctr, Fertil Plus, Auckland, New Zealand
[3] Royal Hosp Women, Androl Unit, Carlton, Vic 3053, Australia
来源：
SEMINARS IN IMMUNOPATHOLOGY | 2007年 / 29卷 / 02期
关键词：
antisperm antibodies; fertility; gamete; sperm; conception;
D O I：
10.1007/s00281-007-0075-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Sperm have been known to be antigenic for more than a century. There is a strong body of evidence that in humans and in other species at least some antibodies that bind to sperm antigens can cause infertility. Therefore, these antibodies are of interest today for two practical reasons. Firstly, the association of the antibodies with infertility means that they must be detected and then the couples treated appropriately. Secondly, because these antibodies can induce infertility they have the potential to be developed for contraceptive purposes in humans and also for the control of feral animal populations.
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收藏
页码：169 / 184
页数：16
相关论文
共 190 条
[91]   RISK-FACTORS FOR ANTISPERM ANTIBODIES IN INFERTILE MEN [J].
HEIDENREICH, A ;
BONFIG, R ;
WILBERT, DM ;
STROHMAIER, WL ;
ENGELMANN, UH .
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1994, 31 (2-3) :69-76
[92]   Binding of human secretory leukocyte protease inhibitor in uterine cervical mucus to immunoglobulins: pathophysiology in immunologic infertility and local immune defense [J].
Hirano, M ;
Kamada, M ;
Maegawa, M ;
Gima, H ;
Aono, T .
FERTILITY AND STERILITY, 1999, 71 (06) :1108-1114
[93]   LIGHT AND ELECTRON-MICROSCOPIC IMMUNOLOCALIZATION OF SPERM PROTEINS IDENTIFIED BY MONOCLONAL-ANTIBODIES FROM THE WORLD-HEALTH-ORGANIZATION-TASK-FORCE-ON-SPERM-ANTIGENS [J].
HOMYK, M ;
HERR, JC .
JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1992, 22 (03) :237-256
[94]  
HOWE SE, 1991, FERTIL STERIL, V55, P1176
[95]   Immunosuppressive activities in the seminal plasma of infertile men: Relationship to sperm antibodies and autoimmunity [J].
Imade, GE ;
Baker, HWG ;
deKretser, DM ;
Hedger, MP .
HUMAN REPRODUCTION, 1997, 12 (02) :256-262
[96]   IMMUNOGLOBULIN CLASS OF SPERM ANTIBODIES IN CERVICAL-MUCUS FROM INFERTILE WOMEN [J].
INGERSLEV, HJ ;
MOLLER, NPH ;
JAGER, S ;
KREMER, J .
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1982, 2 (06) :296-300
[97]  
INGERSLEV HJ, 1980, FERTIL STERIL, V33, P514
[98]  
JAGER S, 1978, INT J FERTIL, V23, P12
[99]  
JAGER S, 1981, FERTIL STERIL, V36, P784
[100]  
JAGER S, 1981, FERTIL STERIL, V36, P792
567891011121314