Gold-Catalyzed Cycloisomerization Reactions of 2-Tosylaminophenylprop-1-yn-3-ols as a Versatile Approach for Indole Synthesis

被引：116

作者：

Kothandaraman, Prasath ^{[1
]}

Rao, Weidong ^{[1
]}

Foo, Shi Jia ^{[1
]}

Chan, Philip Wai Hong ^{[1
]}

机构：

[1] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 27期

关键词：

gold; homogeneous catalysis; indoles; tandem reactions; unsaturated alcohols; ALLYLIC ALCOHOLS; DIRECT AMINATION; C-C; ALKYNES; PALLADIUM; DERIVATIVES; PLATINUM; BONDS; CYCLOPROPANATION; HYDROAMINATION;

D O I：

10.1002/anie.201000341

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical equation presented) A great combination: A putative indolyl-substituted vinyl gold species generated in situ from AuCl/AgOTf catalyzed the title transformation. Under these reaction conditions, indenyl-fused and 2,3-disubstituted indole derivatives were produced in good to excellent yields of up to 94% (see scheme). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4619 / 4623

页数：5

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