First total synthesis of eudistalbin A

被引：7

作者：

Zhang, Pu Yong ^{[1
]}

Wang, Jun Lei ^{[1
]}

Wan, Sheng Biao ^{[1
]}

Jiang, Tao ^{[1
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 08期

关键词：

beta-Carboline; Eudistalbin A; Pictet-Spengler reaction; Henry reaction; Total synthesis; TUNICATE EUDISTOMA-OLIVACEUM; CYCLIN-DEPENDENT KINASES; BETA-CARBOLINES; INHIBITORS; ALKALOIDS; DNA; DERIVATIVES; ACID;

D O I：

10.1016/j.cclet.2010.03.017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Eudistalbin A was isolated from marine tunicate eudistoma album and possess cytotoxic activity (ED(50) < 3.2 mu g/mL) in vitro against the growth of KB human buccal carinoma cells. The synthetic eudistalbin A showed potent inhibitory activity against the breast carcinoma cell line MDA-231 with an IC(50) value of 2.1 mu mol/L using the metabolic assay MTT. All structures of new compounds were confirmed by (1)H NMR, (13)C NMR, HRMS and optical rotation. (C) 2010 Tao Jiang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：889 / 891

页数：3

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