First total synthesis of eudistalbin A

被引：7

作者：

Zhang, Pu Yong ^{[1
]}

Wang, Jun Lei ^{[1
]}

Wan, Sheng Biao ^{[1
]}

Jiang, Tao ^{[1
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 08期

关键词：

beta-Carboline; Eudistalbin A; Pictet-Spengler reaction; Henry reaction; Total synthesis; TUNICATE EUDISTOMA-OLIVACEUM; CYCLIN-DEPENDENT KINASES; BETA-CARBOLINES; INHIBITORS; ALKALOIDS; DNA; DERIVATIVES; ACID;

D O I：

10.1016/j.cclet.2010.03.017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Eudistalbin A was isolated from marine tunicate eudistoma album and possess cytotoxic activity (ED(50) < 3.2 mu g/mL) in vitro against the growth of KB human buccal carinoma cells. The synthetic eudistalbin A showed potent inhibitory activity against the breast carcinoma cell line MDA-231 with an IC(50) value of 2.1 mu mol/L using the metabolic assay MTT. All structures of new compounds were confirmed by (1)H NMR, (13)C NMR, HRMS and optical rotation. (C) 2010 Tao Jiang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：889 / 891

页数：3

共 50 条

[1] First total synthesis of eudistalbin A
Pu Yong Zhang
ChineseChemicalLetters, 2010, 21 (08) : 889 - 891
[2] First total synthesis of marine alkaloid hyrtiosulawesine
Zhang, Pu Yong
Wan, Sheng Biao
Ren, Su Mei
Jiang, Tao
CHINESE CHEMICAL LETTERS, 2010, 21 (11) : 1307 - 1309
[3] The first total synthesis of fuscain
Liang, Yuan-wei
Liao, Xiao-jian
Wang, Chang-jun
Guo, Jin-zhi
Li, Shuo
Xu, Shi-hai
JOURNAL OF CHEMICAL RESEARCH, 2012, (12) : 736 - 737
[4] Total Synthesis of (+)-Alstonlarsine A
Ferjancic, Zorana
Kukuruzar, Andrej
Bihelovic, Filip
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 61 (39)
[5] First total synthesis of the β-carboline alkaloids trigonostemine A, trigonostemine B and a new synthesis of pityriacitrin and hyrtiosulawesine
Szabo, Timea
Hazai, Viktor
Volk, Balazs
Simig, Gyula
Milen, Matyas
TETRAHEDRON LETTERS, 2019, 60 (22) : 1471 - 1475
[6] Efficient Stereoselective Total Synthesis of (+)-Cryptofolione and the First Synthesis of (-)-Cryptocaryalactone
Balasubramanyam, P.
Reddy, Gandolla Chinna
Salvanna, Nayaki
Das, Biswanath
SYNTHESIS-STUTTGART, 2011, (22): : 3706 - 3710
[7] First Total Synthesis of (±)-Latifolin and Its Antioxidant Mechanism
Dai, Yihua
Liu, Qiaoling
Li, Zhifang
Chen, Weifeng
Liu, Zhongli
CHINESE JOURNAL OF CHEMISTRY, 2015, 33 (11) : 1287 - 1292
[8] First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine
Puvvala, Srinu
Jadhav, Vinod D.
Narkhede, Umesh C.
Karun, M. V. V. S. R. N. Anji
Reddy, Ch. Venkata Ramana
SYNTHESIS-STUTTGART, 2017, 49 (12): : 2768 - 2774
[9] First Total Synthesis of Dermocanarin 2
Yamaguchi, Satoru
Takahashi, Nobuyuki
Yuyama, Daisuke
Sakamoto, Kayo
Suzuki, Keisuke
Matsumoto, Takashi
SYNLETT, 2016, 27 (08) : 1262 - 1268
[10] Total Synthesis of (+)-Daphmanidin E
Weiss, Matthias E.
Carreira, Erick M.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (48) : 11501 - 11505

← 1 2 3 4 5 →