Microfluidic fabrication of microengineered hydrogels and their application in tissue engineering

被引：341
作者：
Chung, Bong Geun [1 ]
Lee, Kwang-Ho [2 ]
Khademhosseini, Ali [3 ,4 ,5 ,6 ]
Lee, Sang-Hoon [7 ]
机构：
[1] Hanyang Univ, Dept Bionano Engn, Ansan, South Korea
[2] Kangwon Natl Univ, Dept Adv Mat Sci & Engn, Chunchon, South Korea
[3] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp,Ctr Biomed Engn, Cambridge, MA 02138 USA
[4] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[5] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA
[6] Tohoku Univ, WPI Adv Inst Mat Res, Satellite Lab, Sendai, Miyagi 980, Japan
[7] Korea Univ, Coll Hlth Sci, Dept Biomed Engn, Seoul, South Korea
来源：
LAB ON A CHIP | 2012年 / 12卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
CELL-LADEN MICROGELS; FLY PHOTOPOLYMERIZATION; FLOW LITHOGRAPHY; SCAFFOLDS; DEVICE; GENERATION; FIBERS; MICROPARTICLES; MEDICINE; NETWORKS;
D O I：
10.1039/c1lc20859d
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Microfluidic technologies are emerging as an enabling tool for various applications in tissue engineering and cell biology. One emerging use of microfluidic systems is the generation of shape-controlled hydrogels (i.e., microfibers, microparticles, and hydrogel building blocks) for various biological applications. Furthermore, the microfluidic fabrication of cell-laden hydrogels is of great benefit for creating artificial scaffolds. In this paper, we review the current development of microfluidic-based fabrication techniques for the creation of fibers, particles, and cell-laden hydrogels. We also highlight their emerging applications in tissue engineering and regenerative medicine.
引用
收藏
页码：45 / 59
页数：15
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