Microfluidic fabrication of microengineered hydrogels and their application in tissue engineering

被引：341

作者：

Chung, Bong Geun ^{[1
]}

Lee, Kwang-Ho ^{[2
]}

Khademhosseini, Ali ^{[3
,4
,5
,6
]}

Lee, Sang-Hoon ^{[7
]}

机构：

[1] Hanyang Univ, Dept Bionano Engn, Ansan, South Korea

[2] Kangwon Natl Univ, Dept Adv Mat Sci & Engn, Chunchon, South Korea

[3] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp,Ctr Biomed Engn, Cambridge, MA 02138 USA

[4] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[5] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[6] Tohoku Univ, WPI Adv Inst Mat Res, Satellite Lab, Sendai, Miyagi 980, Japan

[7] Korea Univ, Coll Hlth Sci, Dept Biomed Engn, Seoul, South Korea

来源：

LAB ON A CHIP | 2012年 / 12卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

CELL-LADEN MICROGELS; FLY PHOTOPOLYMERIZATION; FLOW LITHOGRAPHY; SCAFFOLDS; DEVICE; GENERATION; FIBERS; MICROPARTICLES; MEDICINE; NETWORKS;

D O I：

10.1039/c1lc20859d

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Microfluidic technologies are emerging as an enabling tool for various applications in tissue engineering and cell biology. One emerging use of microfluidic systems is the generation of shape-controlled hydrogels (i.e., microfibers, microparticles, and hydrogel building blocks) for various biological applications. Furthermore, the microfluidic fabrication of cell-laden hydrogels is of great benefit for creating artificial scaffolds. In this paper, we review the current development of microfluidic-based fabrication techniques for the creation of fibers, particles, and cell-laden hydrogels. We also highlight their emerging applications in tissue engineering and regenerative medicine.

引用

页码：45 / 59

页数：15

共 82 条

[1]

Adamson RH, 1998, AM J PHYSIOL-HEART C, V274, pH1885, DOI 10.1152/ajpheart.1998.274.6.H1885

[2] Microfabricated implants for applications in therapeutic delivery, tissue engineering, and biosensing [J].

Ainslie, Kristy M. ;

Desai, Tejal A. .

LAB ON A CHIP, 2008, 8 (11) :1864-1878

[3]

Aymard P, 2001, BIOPOLYMERS, V59, P131, DOI 10.1002/1097-0282(200109)59:3<131::AID-BIP1013>3.0.CO

[4]

2-8

[5] Silk fibroin microfluidic devices [J].

Bettinger, Christopher J. ;

Cyr, Kathleen M. ;

Matsumoto, Akira ;

Langer, Robert ;

Borenstein, Jeffrey T. ;

Kaplan, David L. .

ADVANCED MATERIALS, 2007, 19 (19) :2847-+

[6] Micro fabrication of poly (glycerol-sebacate) for contact guidance applications [J].

Bettinger, CJ ;

Orrick, B ;

Misra, A ;

Langer, R ;

Borenstein, JT .

BIOMATERIALS, 2006, 27 (12) :2558-2565

[7] Three-dimensional microfluidic tissue-engineering scaffolds using a flexible biodegradable polymer [J].

Bettinger, CJ ;

Weinberg, EJ ;

Kulig, KM ;

Vacanti, JP ;

Wang, YD ;

Borenstein, JT ;

Langer, R .

ADVANCED MATERIALS, 2006, 18 (02) :165-+

[8] Microfabrication of three-dimensional engineered scaffolds [J].

Borenstein, Jeffrey T. ;

Weinberg, Eli J. ;

Orrick, Brian K. ;

Sundback, Cathryn ;

Kaazempur-Mofrad, Mohammad R. ;

Vacanti, Joseph P. .

TISSUE ENGINEERING, 2007, 13 (08) :1837-1844

[9] Functional endothelialized microvascular networks with circular cross-sections in a tissue culture substrate [J].

Borenstein, Jeffrey T. ;

Tupper, Malinda M. ;

Mack, Peter J. ;

Weinberg, Eli J. ;

Khalil, Ahmad S. ;

Hsiao, James ;

Garcia-Cardena, Guillermo .

BIOMEDICAL MICRODEVICES, 2010, 12 (01) :71-79

[10] Mechanically Robust and Bioadhesive Collagen and Photocrosslinkable Hyaluronic Acid Semi-Interpenetrating Networks [J].

Brigham, Mark D. ;

Bick, Alexander ;

Lo, Edward ;

Bendali, Amel ;

Burdick, Jason A. ;

Khademhosseini, Ali .

TISSUE ENGINEERING PART A, 2009, 15 (07) :1645-1653

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