Microfluidic fabrication of microengineered hydrogels and their application in tissue engineering

被引：337

作者：

Chung, Bong Geun ^{[1
]}

Lee, Kwang-Ho ^{[2
]}

Khademhosseini, Ali ^{[3
,4
,5
,6
]}

Lee, Sang-Hoon ^{[7
]}

机构：

[1] Hanyang Univ, Dept Bionano Engn, Ansan, South Korea

[2] Kangwon Natl Univ, Dept Adv Mat Sci & Engn, Chunchon, South Korea

[3] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp,Ctr Biomed Engn, Cambridge, MA 02138 USA

[4] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[5] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[6] Tohoku Univ, WPI Adv Inst Mat Res, Satellite Lab, Sendai, Miyagi 980, Japan

[7] Korea Univ, Coll Hlth Sci, Dept Biomed Engn, Seoul, South Korea

来源：

LAB ON A CHIP | 2012年 / 12卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

CELL-LADEN MICROGELS; FLY PHOTOPOLYMERIZATION; FLOW LITHOGRAPHY; SCAFFOLDS; DEVICE; GENERATION; FIBERS; MICROPARTICLES; MEDICINE; NETWORKS;

D O I：

10.1039/c1lc20859d

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Microfluidic technologies are emerging as an enabling tool for various applications in tissue engineering and cell biology. One emerging use of microfluidic systems is the generation of shape-controlled hydrogels (i.e., microfibers, microparticles, and hydrogel building blocks) for various biological applications. Furthermore, the microfluidic fabrication of cell-laden hydrogels is of great benefit for creating artificial scaffolds. In this paper, we review the current development of microfluidic-based fabrication techniques for the creation of fibers, particles, and cell-laden hydrogels. We also highlight their emerging applications in tissue engineering and regenerative medicine.

引用

页码：45 / 59

页数：15

共 82 条

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