Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

被引：1331
作者：
Becker, Annette [1 ,2 ]
Thakur, Basant Kumar [1 ,2 ,4 ]
Weiss, Joshua Mitchell [1 ,2 ]
Kim, Han Sang [1 ,2 ,5 ,6 ]
Peinado, Hector [1 ,2 ,3 ]
Lyden, David [1 ,2 ]
机构：
[1] Weill Cornell Med, Childrens Canc & Blood Fdn Labs, Drukier Inst Childrens Hlth, Dept Pediat,Meyer Canc Ctr, New York, NY 10021 USA
[2] Weill Cornell Med, Childrens Canc & Blood Fdn Labs, Drukier Inst Childrens Hlth, Dept Cell & Dev Biol,Meyer Canc Ctr, New York, NY 10021 USA
[3] Spanish Natl Canc Res Ctr CNIO, Microenvironm & Metastasis Lab, Dept Mol Oncol, Madrid 28029, Spain
[4] Univ Clin Essen, Pediat Clin 3, Hufelandstr 55, D-45147 Essen, Germany
[5] Yonsei Univ, Coll Med, Yonsei Canc Ctr, Div Med Oncol,Dept Internal Med, Seoul 03722, South Korea
[6] Yonsei Univ, Coll Med, Yonsei Canc Ctr, Div Med Oncol,Dept Pharmacol, Seoul 03722, South Korea
来源：
CANCER CELL | 2016年 / 30卷 / 06期
关键词：
MESENCHYMAL STEM-CELLS; TUMOR-DERIVED EXOSOMES; HUMAN PROSTATE-CANCER; TISSUE FACTOR; FAS LIGAND; IN-VIVO; INTERCELLULAR TRANSFER; TRANSFERRIN RECEPTOR; MELANOMA EXOSOMES; MICRORNA CONTENT;
D O I：
10.1016/j.ccell.2016.10.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stomal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.
引用
收藏
页码：836 / 848
页数：13
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