Ligand-free Cu-catalyzed O-arylation of aliphatic diols

被引：10

作者：

Zheng, Yufen ^{[1
]}

Zou, Wenxing ^{[1
]}

Luo, Laichun ^{[1
]}

Chen, Jiabei ^{[1
]}

Lin, Songwen ^{[1
]}

Sun, Qi ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 81期

关键词：

CROSS-COUPLING REACTIONS; ARYL IODIDES; N-ARYLATION; COPPER; ULLMANN; EFFICIENT; HALIDES; PHENOLS; SYSTEM; DERIVATIVES;

D O I：

10.1039/c5ra12529d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Coupling reaction between aryl iodides and aliphatic diols was realized with a ligand-free copper catalyst under mild conditions. This method was successfully applied in the process of scale-up synthesis of medicinal candidate product EMB-3.

引用

页码：66104 / 66108

页数：5

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