Straightforward Three-Component Synthesis of N′,N′′-Disubstituted N -Alkyl-1,3,5-Triazinanes

被引：5

作者：

Kletskov, Alexey V. ^{[1
]}

Frontera, Antonio ^{[2
]}

Sinelshchikova, Anna A. ^{[3
]}

Grigoriev, Mikhail S. ^{[3
]}

Zaytsev, Vladimir P. ^{[1
]}

Grudova, Mariya V. ^{[1
]}

Bunev, Alexander S. ^{[4
]}

Presnukhina, Sofia ^{[5
]}

Shetnev, Anton ^{[5
]}

Zubkov, Fedor I. ^{[1
]}

机构：

[1] Peoples Friendship Univ Russia, Fac Sci, Organ Chem Dept, 6 Miklukho Maklaya St, Moscow 117198, Russia

[2] Univ Illes Balears, Dept Chem, Cita Valldemossa Km 7-7, Palma De Mallorca 07122, Baleares, Spain

[3] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, Leninsky Pr 31,Bld 4, Moscow 119071, Russia

[4] Togliatti State Univ, Med Chem Ctr, 14 Belorusskaya St, Tolyatti 445020, Russia

[5] Yaroslavl State Pedag Univ, Pharmaceut Technol Transfer Ctr, 108 Respublikanskaya St, Yaroslavl 150000, Russia

来源：

SYNLETT | 2020年 / 31卷 / 11期

基金：

俄罗斯基础研究基金会;

关键词：

triazinanes; domino reaction; sulfonamides; amides; amines; thiourea; THIOUREAS; SM;

D O I：

10.1055/s-0039-1690900

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient approaches towards the synthesis of various N-substituted 1,3,5-triazinanes based on a transformation of N -alkyl-1,5,3-dioxazepanes or on a domino reaction involving condensation of various amines, amides, and paraformaldehyde are described for the first time. Mg(ClO (4) ) (2) was shown to be one of the most potent additives for the condensation. The proposed approaches permit the synthesis of a broad spectrum of substituted sym -triazinanes in good yields with relatively easy workup. In the case of the multicomponent reaction, the approach allows the preparation of the target substances from simple and easily accessible reagents. The representatives of the resulting compounds were found to possess no antimicrobial or cytotoxic activity in in vitro bioassays.

引用

页码：1067 / 1072

页数：6

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