共 174 条
PPAR-γ agonists as regulators of microglial activation and brain inflammation
被引:185
作者:

Bernardo, A
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机构:
Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy

Minghetti, L
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Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy
机构:
[1] Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy
关键词:
CNS;
inflammation;
microglial activation;
neurodegenerations;
NSAIDs;
PPAR-gamma;
15d-PGJ(2);
TZDs;
D O I:
10.2174/138161206780574579
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) belongs to a large group of nuclear receptors controlling reproduction, metabolism, development and immune response. Upon activation by specific agonists, these receptors form dimers and translocate to the nucleus, where they act as agonist-dependent transcription factors and regulate gene expression by binding to specific promoter regions of target genes. The observation that PPAR-gamma is involved in the regulation of macrophage differentiation and activation in the peripheral organs has prompted the investigation of the functional role of PPAR-gamma in microglial cells, the main macrophage population of the CNS. The present review summarizes the several lines of evidence supporting that PPAR-gamma natural and synthetic agonists may control brain inflammation by inhibiting several functions associated to microglial activation, such as the expression of surface antigens and the synthesis of nitric oxide, prostaglandins, inflammatory cytokines and chemokines. Moreover, one of the major natural PPAR-gamma agonist, 15d-prostaglandin J(2) may contribute to the safe elimination of activated microglia by inducing apoptosis. Synthetic PPAR-gamma agonists do not entirely reproduce the range of 15d-prostaglandin J(2) effects, suggesting that PPAR-gamma independent mechanisms are also involved in the action of this prostaglandin. In addition to microglia, PPAR-gamma agonists affect functions and survival of other neural cells, including astrocytes, oligodendrocytes and neurons. Although most of the evidence comes from in vitro observations, an increasing number of studies in animal models further supports the potential therapeutic use of PPAR-gamma agonists in human brain diseases including multiple sclerosis, Parkinson's disease and Alzheimer's disease.
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页码:93 / 109
页数:17
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共 174 条
[1]
Comparative effects of englitazone and glyburide on gluconeogenesis and glycolysis in the isolated perfused rat liver
[J].
Adams, MD
;
Raman, P
;
Judd, RL
.
BIOCHEMICAL PHARMACOLOGY,
1998, 55 (11)
:1915-1920

Adams, MD
论文数: 0 引用数: 0
h-index: 0
机构:
NE Louisiana Univ, Sch Pharm, Div Mol Pharmacol, Coll Pharm & Hlth Sci, Monroe, LA 71209 USA NE Louisiana Univ, Sch Pharm, Div Mol Pharmacol, Coll Pharm & Hlth Sci, Monroe, LA 71209 USA

Raman, P
论文数: 0 引用数: 0
h-index: 0
机构:
NE Louisiana Univ, Sch Pharm, Div Mol Pharmacol, Coll Pharm & Hlth Sci, Monroe, LA 71209 USA NE Louisiana Univ, Sch Pharm, Div Mol Pharmacol, Coll Pharm & Hlth Sci, Monroe, LA 71209 USA

Judd, RL
论文数: 0 引用数: 0
h-index: 0
机构:
NE Louisiana Univ, Sch Pharm, Div Mol Pharmacol, Coll Pharm & Hlth Sci, Monroe, LA 71209 USA NE Louisiana Univ, Sch Pharm, Div Mol Pharmacol, Coll Pharm & Hlth Sci, Monroe, LA 71209 USA
[2]
Diclofenac antagonizes peroxisome proliferator-activated receptor-γ signaling
[J].
Adamson, DJA
;
Frew, D
;
Tatoud, R
;
Wolf, CR
;
Palmer, CNA
.
MOLECULAR PHARMACOLOGY,
2002, 61 (01)
:7-12

Adamson, DJA
论文数: 0 引用数: 0
h-index: 0
机构:
Ninewells Hosp, Biomed Res Ctr, Imperial Canc Res Fund, Mol Pharmacol Unit, Dundee DD1 9SY, Scotland Ninewells Hosp, Biomed Res Ctr, Imperial Canc Res Fund, Mol Pharmacol Unit, Dundee DD1 9SY, Scotland

Frew, D
论文数: 0 引用数: 0
h-index: 0
机构:
Ninewells Hosp, Biomed Res Ctr, Imperial Canc Res Fund, Mol Pharmacol Unit, Dundee DD1 9SY, Scotland Ninewells Hosp, Biomed Res Ctr, Imperial Canc Res Fund, Mol Pharmacol Unit, Dundee DD1 9SY, Scotland

Tatoud, R
论文数: 0 引用数: 0
h-index: 0
机构:
Ninewells Hosp, Biomed Res Ctr, Imperial Canc Res Fund, Mol Pharmacol Unit, Dundee DD1 9SY, Scotland Ninewells Hosp, Biomed Res Ctr, Imperial Canc Res Fund, Mol Pharmacol Unit, Dundee DD1 9SY, Scotland

Wolf, CR
论文数: 0 引用数: 0
h-index: 0
机构:
Ninewells Hosp, Biomed Res Ctr, Imperial Canc Res Fund, Mol Pharmacol Unit, Dundee DD1 9SY, Scotland Ninewells Hosp, Biomed Res Ctr, Imperial Canc Res Fund, Mol Pharmacol Unit, Dundee DD1 9SY, Scotland

Palmer, CNA
论文数: 0 引用数: 0
h-index: 0
机构:
Ninewells Hosp, Biomed Res Ctr, Imperial Canc Res Fund, Mol Pharmacol Unit, Dundee DD1 9SY, Scotland Ninewells Hosp, Biomed Res Ctr, Imperial Canc Res Fund, Mol Pharmacol Unit, Dundee DD1 9SY, Scotland
[3]
The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease
[J].
Aisen, PS
.
LANCET NEUROLOGY,
2002, 1 (05)
:279-284

Aisen, PS
论文数: 0 引用数: 0
h-index: 0
机构:
Georgetown Univ, Ctr Med, Dept Neurol, Washington, DC 20007 USA Georgetown Univ, Ctr Med, Dept Neurol, Washington, DC 20007 USA
[4]
Prolonged exposure of microglia to lipopolysaccharide modifies the intracellular signaling pathways and selectively promotes prostaglandin E2 synthesis
[J].
Ajmone-Cat, MA
;
Nicolini, A
;
Minghetti, L
.
JOURNAL OF NEUROCHEMISTRY,
2003, 87 (05)
:1193-1203

Ajmone-Cat, MA
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy

Nicolini, A
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy

Minghetti, L
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy
[5]
Inflammation and Alzheimer's disease
[J].
Akiyama, H
;
Barger, S
;
Barnum, S
;
Bradt, B
;
Bauer, J
;
Cole, GM
;
Cooper, NR
;
Eikelenboom, P
;
Emmerling, M
;
Fiebich, BL
;
Finch, CE
;
Frautschy, S
;
Griffin, WST
;
Hampel, H
;
Hull, M
;
Landreth, G
;
Lue, LF
;
Mrak, R
;
Mackenzie, IR
;
McGeer, PL
;
O'Banion, MK
;
Pachter, J
;
Pasinetti, G
;
Plata-Salaman, C
;
Rogers, J
;
Rydel, R
;
Shen, Y
;
Streit, W
;
Strohmeyer, R
;
Tooyoma, I
;
Van Muiswinkel, FL
;
Veerhuis, R
;
Walker, D
;
Webster, S
;
Wegrzyniak, B
;
Wenk, G
;
Wyss-Coray, T
.
NEUROBIOLOGY OF AGING,
2000, 21 (03)
:383-421

Akiyama, H
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Barger, S
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Barnum, S
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Bradt, B
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Bauer, J
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Cole, GM
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Cooper, NR
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Eikelenboom, P
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Emmerling, M
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Fiebich, BL
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Finch, CE
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Frautschy, S
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Griffin, WST
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Hampel, H
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Hull, M
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Landreth, G
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Lue, LF
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Mrak, R
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Mackenzie, IR
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

McGeer, PL
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

O'Banion, MK
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Pachter, J
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Pasinetti, G
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Plata-Salaman, C
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Rogers, J
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Rydel, R
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Shen, Y
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Streit, W
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Strohmeyer, R
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Tooyoma, I
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Van Muiswinkel, FL
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Veerhuis, R
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Walker, D
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Webster, S
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Wegrzyniak, B
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Wenk, G
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA

Wyss-Coray, T
论文数: 0 引用数: 0
h-index: 0
机构:
Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA
[6]
PPARγ, the ultimate thrifty gene
[J].
Auwerx, J
.
DIABETOLOGIA,
1999, 42 (09)
:1033-1049

Auwerx, J
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Pasteur, LBRE, F-59019 Lille, France Inst Pasteur, LBRE, F-59019 Lille, France
[7]
Biosynthesis of 15-deoxy-Δ12,14-PGJ2 and the litigation of PPARγ
[J].
Bell-Parikh, LC
;
Ide, T
;
Lawson, JA
;
McNamara, P
;
Reilly, M
;
FitzGerald, GA
.
JOURNAL OF CLINICAL INVESTIGATION,
2003, 112 (06)
:945-955

Bell-Parikh, LC
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA

Ide, T
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA

Lawson, JA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA

McNamara, P
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA

Reilly, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA

FitzGerald, GA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA
[8]
Evidence for the presence of both peroxisome proliferator-activated receptors alpha and beta in the rat spinal cord
[J].
Benani, A
;
Krémarik-Bouillaud, P
;
Bianchi, A
;
Netter, P
;
Minn, A
;
Dauça, M
.
JOURNAL OF CHEMICAL NEUROANATOMY,
2003, 25 (01)
:29-38

Benani, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nancy 1, Lab Biol Cellulaire Dev, Fac Sci, F-54506 Vandoeuvre Les Nancy, France

Krémarik-Bouillaud, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nancy 1, Lab Biol Cellulaire Dev, Fac Sci, F-54506 Vandoeuvre Les Nancy, France

Bianchi, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nancy 1, Lab Biol Cellulaire Dev, Fac Sci, F-54506 Vandoeuvre Les Nancy, France

Netter, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nancy 1, Lab Biol Cellulaire Dev, Fac Sci, F-54506 Vandoeuvre Les Nancy, France

Minn, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nancy 1, Lab Biol Cellulaire Dev, Fac Sci, F-54506 Vandoeuvre Les Nancy, France

Dauça, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nancy 1, Lab Biol Cellulaire Dev, Fac Sci, F-54506 Vandoeuvre Les Nancy, France
[9]
Role of the peroxisome proliferator-activated receptor-γ (PPAR-γ) and its natural ligand 15-deoxy-Δ12,14-prostaglandin J2 in the regulation of microglial functions
[J].
Bernardo, A
;
Levi, G
;
Minghetti, L
.
EUROPEAN JOURNAL OF NEUROSCIENCE,
2000, 12 (07)
:2215-2223

Bernardo, A
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Super Sanita, Lab Pathophysiol, Neurobiol Sect, I-00161 Rome, Italy Ist Super Sanita, Lab Pathophysiol, Neurobiol Sect, I-00161 Rome, Italy

Levi, G
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Super Sanita, Lab Pathophysiol, Neurobiol Sect, I-00161 Rome, Italy Ist Super Sanita, Lab Pathophysiol, Neurobiol Sect, I-00161 Rome, Italy

Minghetti, L
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Super Sanita, Lab Pathophysiol, Neurobiol Sect, I-00161 Rome, Italy Ist Super Sanita, Lab Pathophysiol, Neurobiol Sect, I-00161 Rome, Italy
[10]
15-Deoxy-Δ12,14-prostaglandin J2 regulates the functional state and the survival of microglial cells through multiple molecular mechanisms
[J].
Bernardo, A
;
Ajmone-Cat, MA
;
Levi, G
;
Minghetti, L
.
JOURNAL OF NEUROCHEMISTRY,
2003, 87 (03)
:742-751

Bernardo, A
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy

Ajmone-Cat, MA
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy

Levi, G
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy

Minghetti, L
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy