White adipocytes: More than just fat depots

被引：50
|
作者：
Henry, Sarah L. [1 ]
Bensley, Jonathan G. [1 ]
Wood-Bradley, Ryan J. [1 ]
Cullen-McEwen, Luise A. [1 ]
Bertram, John F. [1 ]
Armitage, James A. [1 ]
机构：
[1] Monash Univ, Sch Biomed Sci, Dept Anat & Dev Biol, Clayton, Vic 3800, Australia
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2012年 / 44卷 / 03期
关键词：
Adipocyte; Obesity; Adipose tissue metabolism; Obesity related hypertension; Developmental programming of health and disease; NECROSIS-FACTOR-ALPHA; ADIPOSE-TISSUE; STEM-CELLS; LEPTIN; ADIPOGENESIS; METABOLISM; DIFFERENTIATION; ENDOCRINE; EXPOSURE; DISEASE;
D O I：
10.1016/j.biocel.2011.12.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Globally 30% of adults are overweight or obese. The white adipocyte is a major component of adipose tissue, and as the obesity epidemic increases it is critically important to understand the factors determining adipocyte development and function. Adipogenesis has two distinct phases; determination of the adipocyte from a multipotent stem cell, and terminal differentiation of a pre-adipocyte into a mature adipocyte. The environment encountered in early life can alter adipocyte number and size and potentially impact upon adipocyte endocrine function in adulthood. These alterations may contribute to the pathophysiology of chronic diseases and thus targeted therapy of the adipocyte has great potential for treating the current obesity epidemic. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：435 / 440
页数：6
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