The genus Xenopus as a multispecies model for evolutionary and comparative immunobiology of the 21st century

被引：36

作者：

Robert, Jacques ^{[1
]}

Cohen, Nicholas ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Dept Microbiol & Immunol, Rochester, NY 14642 USA

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2011年 / 35卷 / 09期

基金：

美国国家科学基金会;

关键词：

Immunogenetics; Tumor immunity; Nonclassical MHC class I; Genome evolution; GLOBAL AMPHIBIAN DECLINES; T-CELL RESPONSES; CLASS-I ANTIGENS; MHC CLASS IA; PHYLOGENETIC CONSERVATION; IMMUNE-SYSTEM; CLAWED FROG; LAEVIS; ONTOGENY; GENES;

D O I：

10.1016/j.dci.2011.01.014

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

The Xenopus model for immunological research offers a collection of invaluable research tools including MHC-defined clones, inbred strains, cell lines, and monoclonal antibodies. Further, the annotated full genome sequence of Xenopus tropicalis and its remarkable conservation of gene organization with mammals, as well as ongoing genome mapping and mutagenesis studies in X. tropicalis, add a new dimension to the study of immunity. In this paper, we review uses of this amphibian model to study: the development of the immune system; vascular and lymphatic regeneration: immune tolerance; tumor immunity; immune responses to important emerging infectious diseases; and the evolution of classical and nonclassical MHC class I genes. We also discuss the rich potential of the species with different degrees of polypoidy resulting from whole genome-wide duplication of the Xenopodinae subfamily as a model to study regulation at the genome level. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：916 / 923

页数：8

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