Neurological complications of celiac disease and autoimmune mechanisms: A prospective study

被引：91

作者：

Briani, Chiara ^{[1
]}

Zara, Gabriella ^{[1
]}

Alaedini, Armin ^{[2
]}

Grassivaro, Francesca ^{[1
]}

Ruggero, Susanna ^{[1
]}

Toffanin, Elisabetta ^{[1
]}

Albergoni, Maria Paola ^{[3
]}

Luca, Milena ^{[3
]}

Giometto, Bruno ^{[4
]}

Ermani, Mario ^{[1
]}

De Lazzari, Franca ^{[5
]}

D'Odorico, Anna ^{[5
]}

Battistin, Leontino ^{[1
,6
]}

机构：

[1] Univ Padua, Dept Neurosci, I-35128 Padua, Italy

[2] Cornell Univ, Dept Neurol & Neurosci, New York, NY 10021 USA

[3] Univ Padua, Blood Transfus Serv, I-35128 Padua, Italy

[4] Ca Foncello Hosp, Dept Neurol, Treviso, Italy

[5] Univ Padua, Dept Med & Surg Sci, I-35128 Padua, Italy

[6] San Camillo Hosp, IRCCS, Venice, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 195卷 / 1-2期

关键词：

celiac disease; antibodies; gluten; neuropathy; diet;

D O I：

10.1016/j.jneuroim.2008.01.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Humoral immune mechanisms may have a role in the neurological complications of celiac disease (CD). We assessed 71 CID patients for neurologic manifestations and presence of serum antibodies to neural antigens. Sixteen patients (22.5%) were found to have neurological deficits including headache, depression, entrapment syndromes, peripheral neuropathy, and epilepsy. Antibody reactivity to neural antigens was detected in 30/71 (42.2%) patients. There was no clear correlation between anti-neural reactivity and neurologic dysfunction. Follow-up of 62 patients did not reveal change in electrophysiology or antibodies, regardless of diet. However, in 2 patients with neuropathy, symptoms improved or worsened depending on the diet. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：171 / 175

页数：5

共 23 条

[1] Ganglioside reactive antibodies in the neuropathy associated with celiac disease [J].