Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

被引:1733
作者
Guilherme, Adilson [1 ]
Virbasius, Joseph V. [1 ]
Puri, Vishwajeet [1 ]
Czech, Michael P. [1 ]
机构
[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
关键词
D O I
10.1038/nrm2391
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Acquired resistance to the action of insulin to stimulate glucose transport in skeletal muscle is associated with obesity and promotes the development of type 2 diabetes. In skeletal muscle, insulin resistance can result from high levels of circulating fatty acids that disrupt insulin signalling pathways. However, the severity of insulin resistance varies greatly among obese people. Here we postulate that this variability might reflect differences in levels of lipid-droplet proteins that promote the sequestration of fatty acids within adipocytes in the form of triglycerides, thereby lowering exposure of skeletal muscle to the inhibitory effects of fatty acids.
引用
收藏
页码:367 / 377
页数:11
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