Multiplexed DNA Detection with DNA-Functionalized Silver and Silver/Gold Nanoparticle Superstructure Probes

被引：12

作者：

Kim, Ji-Young ^{[1
]}

Lee, Jae-Seung ^{[1
]}

机构：

[1] Korea Univ, Dept Mat Sci & Engn, Seoul 136713, South Korea

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2012年 / 33卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

DNA; SPR; Nanoparticle superstructure; Multiplexing; Colorimetric detection; ENHANCED RAMAN-SCATTERING; SPECTROSCOPY; FABRICATION; CRYSTALS; ARRAYS;

D O I：

10.5012/bkcs.2012.33.1.221

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA-functionalized silver and silver/gold bimetallic nanoparticle superstructure probes with controllable sizes and optical properties are synthesized using monothiol DNA and dithiothreitol. The superstructures exhibit a very narrow size distribution, which can be easily controlled by balancing the ratio of dithiothreitol and DNA. These superstructures assemble reversibly in a highly cooperative manner, and are SERS active. Multiplexed colorimetric detection of DNA targets using these superstructure probes has been demonstrated to identify three different DNA target sequences that are associated with three lethal diseases, respectively.

引用

页码：221 / 226

页数：6

共 35 条

[1] Surface-enhanced Raman spectroscopy for DNA detection by nanoparticle assembly onto smooth metal films [J].

Braun, Gary ;

Lee, Seung Joon ;

Dante, Mark ;

Nguyen, Thuc-Quyen ;

Moskovits, Martin ;

Reich, Norbert .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (20) :6378-+

[2] Preparation of Unique 1-D Nanoparticle Superstructures and Tailoring their Structural Features [J].

Chen, Chun-Long ;

Rosi, Nathaniel L. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (20) :6902-+

[3] Synthesis of AgcoreAushell bimetallic nanoparticles for immunoassay based on surface-enhanced Raman spectroscopy [J].

Cui, Y ;

Ren, B ;

Yao, JL ;

Gu, RA ;

Tian, ZQ .

JOURNAL OF PHYSICAL CHEMISTRY B, 2006, 110 (09) :4002-4006

[4] Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species [J].

Cui, Y ;

Wei, QQ ;

Park, HK ;

Lieber, CM .

SCIENCE, 2001, 293 (5533) :1289-1292

[5] Biomolecular screening with encoded porous-silicon photonic crystals [J].

Cunin, F ;

Schmedake, TA ;

Link, JR ;

Li, YY ;

Koh, J ;

Bhatia, SN ;

Sailor, MJ .

NATURE MATERIALS, 2002, 1 (01) :39-41

[6] Evaluation of surface-enhanced resonance Raman scattering for quantitative DNA analysis [J].

Faulds, K ;

Smith, WE ;

Graham, D .

ANALYTICAL CHEMISTRY, 2004, 76 (02) :412-417

[7] Control of enhanced Raman scattering using a DNA-based assembly process of dye-coded nanoparticles [J].

Graham, Duncan ;

Thompson, David G. ;

Smith, W. Ewen ;

Faulds, Karen .

NATURE NANOTECHNOLOGY, 2008, 3 (09) :548-551

[8] Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules [J].

Han, MY ;

Gao, XH ;

Su, JZ ;

Nie, S .

NATURE BIOTECHNOLOGY, 2001, 19 (07) :631-635

[9] Nanosphere lithography: Size-tunable silver nanoparticle and surface cluster arrays [J].

Hulteen, JC ;

Treichel, DA ;

Smith, MT ;

Duval, ML ;

Jensen, TR ;

Van Duyne, RP .

JOURNAL OF PHYSICAL CHEMISTRY B, 1999, 103 (19) :3854-3863

[10] Bimetallic silver-gold nanowires: fabrication and use in surface-enhanced Raman scattering [J].

Hunyadi, Simona E. ;

Murphy, Catherine J. .

JOURNAL OF MATERIALS CHEMISTRY, 2006, 16 (40) :3929-3935

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