Staphylococcus aureus, master manipulator of the human hemostatic system

被引：97
作者：
Liesenborghs, L. [1 ]
Verhamme, P. [1 ]
Vanassche, T. [1 ]
机构：
[1] KULeuven, Univ Hosp Leuven, Dept Cardiovasc Sci, Ctr Mol & Vasc Biol, Herestr 49, B-3000 Leuven, Belgium
来源：
JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2018年 / 16卷 / 03期
关键词：
infective endocarditis; sepsis; staphylocoagulase; staphylococcus aureus; staphylokinase; VON-WILLEBRAND-FACTOR; FACTOR-BINDING-PROTEIN; EXTRACELLULAR ADHERENCE PROTEIN; CLUMPING FACTOR-B; PLATELET MICROBICIDAL PROTEIN; FC-GAMMA-RIIA; EXPERIMENTAL ENDOCARDITIS; HOST-DEFENSE; IN-VITRO; INFECTIVE ENDOCARDITIS;
D O I：
10.1111/jth.13928
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The coagulation system does not only offer protection against bleeding, but also aids in our defense against invading microorganisms. The hemostatic system and innate immunity are strongly entangled, which explains why so many infections are complicated by either bleeding or thrombosis. Staphylococcus aureus (S. aureus), currently the most deadly infectious agent in the developed world, causes devastating intravascular infections such as sepsis and infective endocarditis. During these infections S. aureus comes in close contact with the host hemostatic system and proves to be a master in manipulating coagulation. The coagulases of S. aureus directly induce coagulation by activating prothrombin. S. aureus also manipulates fibrinolysis by triggering plasminogen activation via staphylokinase. Furthermore, S. aureus binds and activates platelets and interacts with key coagulation proteins such as fibrin(ogen), fibronectin and von Willebrand factor. By manipulating the coagulation system S. aureus gains a significant advantage over the host defense mechanisms. Studying the interplay between S. aureus and the hemostatic system can therefore lead to new innovative therapies for battling S. aureus infections.
引用
收藏
页码：441 / 454
页数：14
相关论文
共 106 条
[1]   Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4 [J].
Arman, Monica ;
Krauel, Krystin ;
Tilley, Dorothea O. ;
Weber, Claudia ;
Cox, Dermot ;
Greinacher, Andreas ;
Kerrigan, Steven W. ;
Watson, Steve P. .
BLOOD, 2014, 123 (20) :3166-3174
[2]  
ARVAND M, 1990, J BIOL CHEM, V265, P14377
[3]   VIRULENCE OF COAGULASE-DEFICIENT MUTANTS OF STAPHYLOCOCCUS-AUREUS IN EXPERIMENTAL ENDOCARDITIS [J].
BADDOUR, LM ;
TAYIDI, MM ;
WALKER, E ;
MCDEVITT, D ;
FOSTER, TJ .
JOURNAL OF MEDICAL MICROBIOLOGY, 1994, 41 (04) :259-263
[4]   Staphylococcal Extracellular Adherence Protein Induces Platelet Activation by Stimulation of Thiol Isomerases [J].
Bertling, Anne ;
Niemann, Silke ;
Hussain, Muzaffar ;
Holbrook, Lisa ;
Stanley, Ronald G. ;
Brodde, Martin F. ;
Pohl, Silke ;
Schifferdecker, Tina ;
Roth, Joachim ;
Jurk, Kerstin ;
Mueller, Anja ;
Lahav, Judith ;
Peters, Georg ;
Heilmann, Christine ;
Gibbins, Jonathan M. ;
Kehrel, Beate E. .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012, 32 (08) :1979-1990
[5]   The von Willebrand factor-binding protein (vWbp) of Staphylococcus aureus is a coagulase [J].
Bjerketorp, J ;
Jacobsson, K ;
Frykberg, L .
FEMS MICROBIOLOGY LETTERS, 2004, 234 (02) :309-314
[6]   Staphylococcus aureus interactions with the endothelium -: The role of bacterial "Secretable Expanded Repertoire Adhesive Molecules" (SERAM) in disturbing host defense systems [J].
Chavakis, T ;
Wiechmann, K ;
Preissner, KT ;
Herrmann, M .
THROMBOSIS AND HAEMOSTASIS, 2005, 94 (02) :278-285
[7]   Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes [J].
Chavakis, T ;
Hussain, M ;
Kanse, SM ;
Peters, G ;
Bretzel, RG ;
Flock, JI ;
Herrmann, M ;
Preissner, KT .
NATURE MEDICINE, 2002, 8 (07) :687-693
[8]   Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity [J].
Cheng, Alice G. ;
McAdow, Molly ;
Kim, Hwan K. ;
Bae, Taeok ;
Missiakas, Dominique M. ;
Schneewind, Olaf .
PLOS PATHOGENS, 2010, 6 (08) :19-20
[9]   Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues [J].
Cheng, Alice G. ;
Kim, Hwan Keun ;
Burts, Monica L. ;
Krausz, Thomas ;
Schneewind, Olaf ;
Missiakas, Dominique M. .
FASEB JOURNAL, 2009, 23 (10) :3393-3404
[10]   Clumping factor A, von Willebrand factor-binding protein and von Willebrand factor anchor Staphylococcus aureus to the vessel wall [J].
Claes, J. ;
Liesenborghs, L. ;
Peetermans, M. ;
Veloso, T. R. ;
Missiakas, D. ;
Schneewind, O. ;
Mancini, S. ;
Entenza, J. M. ;
Hoylaerts, M. F. ;
Heying, R. ;
Verhamme, P. ;
Vanassche, T. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2017, 15 (05) :1009-1019
12345678910