prM-antibody renders immature West Nile virus infectious in vivo

被引：25

作者：

Colpitts, Tonya M. ^{[3
]}

Rodenhuis-Zybert, Izabela ^{[1
,2
]}

Moesker, Bastiaan ^{[1
,2
]}

Wang, Penghua ^{[3
]}

Fikrig, Erol ^{[3
]}

Smit, Jolanda M. ^{[1
,2
]}

机构：

[1] Univ Med Ctr Groningen, Sect Mol Virol, Dept Med Microbiol, NL-9713 AV Groningen, Netherlands

[2] Univ Groningen, Groningen, Netherlands

[3] Yale Univ, Sch Med, Infect Dis Sect, Dept Internal Med,Howard Hughes Med Inst, New Haven, CT 06520 USA

来源：

JOURNAL OF GENERAL VIROLOGY | 2011年 / 92卷

关键词：

BORNE ENCEPHALITIS-VIRUS; DENGUE VIRUS; DEPENDENT ENHANCEMENT; FLAVIVIRUS; FUSION; MATURATION; CLEAVAGE; VIRIONS; ENTRY; FURIN;

D O I：

10.1099/vir.0.031427-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

West Nile virus (WNV) is a member of the family Flaviviridae and is a neurotropic pathogen responsible for severe human disease. Flavivirus-infected cells release virus particles that contain variable numbers of precursor membrane (prM) protein molecules at the viral surface. Consequently, antibodies are produced against the prM protein. These antibodies have been shown to activate the infectious potential of fully immature flavivirus particles in vitro. Here, we provide in vivo proof that prM antibodies render immature WNV infectious. Infection with antibody-opsonized immature WNV particles caused disease and death of mice, and infectious WNV was found in the brains and sera.

引用

页码：2281 / 2285

页数：5

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