IL-10 Neutralization Promotes Parasite Clearance in Splenic Aspirate Cells From Patients With Visceral Leishmaniasis

被引：144

作者：

Gautam, Shalini ^{[2
]}

Kumar, Rajiv ^{[2
]}

Maurya, Radheshyam ^{[2
,3
]}

Nylen, Susanne ^{[1
,4
]}

Ansari, Nasim ^{[1
]}

Rai, Madhukar ^{[2
]}

Sundar, Shyam ^{[2
]}

Sacks, David ^{[1
]}

机构：

[1] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[2] Banaras Hindu Univ, Inst Med Sci, Dept Med, Varanasi 221005, Uttar Pradesh, India

[3] Univ Hyderabad, Dept Anim Sci, Sch Life Sci, Hyderabad 500134, Andhra Pradesh, India

[4] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 204卷 / 07期

基金：

美国国家卫生研究院;

关键词：

REGULATORY T-CELLS; IMMUNE-RESPONSES; INTERLEUKIN-10; TUBERCULOSIS; INFECTION;

D O I：

10.1093/infdis/jir461

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanisms underlying the failure to contain the growth of Leishmania parasites in human visceral leishmaniasis (VL) are not understood. L donovani amastigotes were quantified in cultured splenic aspirate cells to assess the function of IL-10 in lesional tissue ex vivo. In 67 patients with active VL, IL-10 neutralization promoted parasite killing in 73% and complete clearance in 30%, while 18% had more parasites and 9% did not change. The splenic cells secreted increased levels of both tumor necrosis factor a (TNF alpha) and interferon gamma (IFN gamma) under IL-10-neutralizing conditions. These findings provide direct support for targeting IL-10 as an approach to therapy in human VL.

引用

页码：1134 / 1137

页数：4

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