Prospects for Protective Potential of Moringa oleifera against Kidney Diseases

被引：27
作者：
Akter, Tanzina [1 ]
Rahman, Md Atikur [1 ]
Moni, Akhi [1 ]
Apu, Md. Aminul Islam [1 ]
Fariha, Atqiya [1 ]
Hannan, Md. Abdul [1 ,2 ]
Uddin, Md Jamal [1 ,3 ]
机构：
[1] ABEx Biores Ctr, Dhaka 1230, Bangladesh
[2] Bangladesh Agr Univ, Dept Biochem & Mol Biol, Mymensingh 2202, Bangladesh
[3] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Coll Pharm, Seoul 03760, South Korea
来源：
PLANTS-BASEL | 2021年 / 10卷 / 12期
基金：
新加坡国家研究基金会;
关键词：
Moringa oleifera; antioxidant; anti-aging; fibrosis; inflammation; kidney disease; INDUCED OXIDATIVE STRESS; NITRIC-OXIDE SYNTHASE; INDUCED NEPHROTOXICITY; ISCHEMIA-REPERFUSION; EXTRACT; INHIBITION; APOPTOSIS; INJURY; LEAVES; DAMAGE;
D O I：
10.3390/plants10122818
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Kidney diseases are regarded as one of the major public health issues in the world. The objectives of this study were: (i) to investigate the causative factors involved in kidney disease and the therapeutic aspects of Moringa oleifera, as well as (ii) the effectiveness of M. oleifera in the anti-inflammation and antioxidant processes of the kidney while minimizing all potential side effects. In addition, we proposed a hypothesis to improve M. oleifera based drug development. This study was updated by searching the key words M. oleifera on kidney diseases and M. oleifera on oxidative stress, inflammation, and fibrosis in online research databases such as PubMed and Google Scholar. The following validation checking and scrutiny analysis of the recently published articles were used to explore this study. The recent existing research has found that M. oleifera has a plethora of health benefits. Individual medicinal properties of M. oleifera leaf extract, seed powder, stem extract, and the whole extract (ethanol/methanol) can up-increase the activity of antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), while decreasing the activity of inflammatory cytokines such as TNF-alpha, IL-1 beta, IL-6, and COX-2. In our study, we have investigated the properties of this plant against kidney diseases based on existing knowledge with an updated review of literature. Considering the effectiveness of M. oleifera, this study would be useful for further research into the pharmacological potential and therapeutic insights of M. oleifera, as well as prospects of Moringa-based effective medicine development for human benefits.
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页数：15
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