Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?

被引：81
作者：
Flynn, Michael G. [1 ,2 ]
Markofski, Melissa M. [3 ]
Carrillo, Andres E. [4 ,5 ]
机构：
[1] HCA South Atlantic Div, Charleston, SC 29492 USA
[2] Coll Charleston, Charleston, SC 29424 USA
[3] Univ Houston, Dept Hlth & Human Performance, Houston, TX 77204 USA
[4] Chatham Univ, Dept Exercise Sci, Pittsburgh, PA 15232 USA
[5] Univ Thessaly, Dept Exercise Sci, FAME Lab, Trikala, Greece
来源：
AGING AND DISEASE | 2019年 / 10卷 / 01期
关键词：
inflammation; exercise; physical activity; immune system; gerontology; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; AGE-INDUCED CHANGES; PHYSICAL-ACTIVITY; INSULIN-RESISTANCE; SKELETAL-MUSCLE; SYSTEMIC INFLAMMATION; WEIGHT-LOSS; PSYCHOSOCIAL FACTORS; AEROBIC EXERCISE;
D O I：
10.14336/AD.2018.0326
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Age-associated hyper-inflammation or "inflamm-aging" has been linked to the development of chronic diseases and characterized as an unavoidable aspect of aging. However, the inflamm-aging model does not adequately address the potential anti-inflammatory effects of exercise training and the potential for exercise to ameliorate several age-related diseases. In this brief review, we introduce a new paradigm-inflamm-inactivity-that describes a potent counter-measure to age-associated inflammatory illness.
引用
收藏
页码：147 / 156
页数：10
相关论文
共 93 条
[1]   Physical training reduces peripheral markers of inflammation in patients with chronic heart failure [J].
Adamopoulos, S ;
Parissis, J ;
Kroupis, C ;
Georgiadis, M ;
Karatzas, D ;
Karavolias, G ;
Koniavitou, K ;
Coats, AJS ;
Kremastinos, DT .
EUROPEAN HEART JOURNAL, 2001, 22 (09) :791-797
[2]   Exercise and the Regulation of Inflammatory Responses [J].
Allen, Jacob ;
Sun, Yi ;
Woods, Jeffrey A. .
MOLECULAR AND CELLULAR REGULATION OF ADAPTATION TO EXERCISE, 2015, 135 :337-354
[3]   Effects of combined training vs aerobic training on cognitive functions in COPD: a randomized controlled trial [J].
Aquino, Giovanna ;
Iuliano, Enzo ;
di Cagno, Alessandra ;
Vardaro, Angela ;
Fiorilli, Giovanni ;
Moffa, Stefano ;
Di Costanzo, Alfonso ;
De Simone, Giuseppe ;
Calcagno, Giuseppe .
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2016, 11 :711-718
[4]   Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].
Arita, Y ;
Kihara, S ;
Ouchi, N ;
Takahashi, M ;
Maeda, K ;
Miyagawa, J ;
Hotta, K ;
Shimomura, I ;
Nakamura, T ;
Miyaoka, K ;
Kuriyama, H ;
Nishida, M ;
Yamashita, S ;
Okubo, K ;
Matsubara, K ;
Muraguchi, M ;
Ohmoto, Y ;
Funahashi, T ;
Matsuzawa, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83
[5]   Older Adults, Chronic Disease and Leisure-Time Physical Activity [J].
Ashe, Maureen C. ;
Miller, William C. ;
Eng, Janice J. ;
Noreau, Luc .
GERONTOLOGY, 2009, 55 (01) :64-72
[6]  
Ashton WD, 2000, J CARDIOVASC RISK, V7, P259
[7]   Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease [J].
Bassuk, SS ;
Manson, JE .
JOURNAL OF APPLIED PHYSIOLOGY, 2005, 99 (03) :1193-1204
[8]   Exercise and gene expression: physiological regulation of the human genome through physical activity [J].
Booth, FW ;
Chakravarthy, MV ;
Spangenburg, EE .
JOURNAL OF PHYSIOLOGY-LONDON, 2002, 543 (02) :399-411
[9]   Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects [J].
Bruun, JM ;
Helge, JW ;
Richelsen, B ;
Stallknecht, B .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2006, 290 (05) :E961-E967
[10]  
CASPERSEN CJ, 1995, MED SCI SPORT EXER, V27, P713
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