Antimicrobial properties of a novel copper-based composite coating with potential for use in healthcare facilities

被引:87
作者
Montero, David A. [1 ]
Arellano, Carolina [1 ]
Pardo, Mirka [1 ]
Vera, Rosa [2 ]
Galvez, Ricardo [3 ]
Cifuentes, Marcela [3 ]
Berasain, Maria A. [3 ]
Gomez, Marisol [4 ]
Ramirez, Claudio [4 ]
Vidal, Roberto M. [1 ,5 ]
机构
[1] Univ Chile, Inst Ciencias Biomed, Fac Med, Programa Microbiol & Micol, Santiago, Chile
[2] Pontificia Univ Catolica Valparaiso, Fac Ciencias, Inst Quim, Valparaiso, Chile
[3] Hosp Clin Univ Chile, Fac Med, Unidad Cuidados Intens, Santiago, Chile
[4] ATACAMALAB, Lampa, Chile
[5] Univ Chile, Fac Med, Inst Milenio Inmunol & Inmunoterapia, Santiago, Chile
关键词
Antimicrobial copper; Copper-based composite; Self-sanitizing coating; High-touch surfaces; Healthcare-associated infections; NOSOCOMIAL INFECTIONS; ACQUIRED INFECTIONS; SURFACES; REDUCTION; BACTERIA; BURDEN; IMPACT; UNIT;
D O I
10.1186/s13756-018-0456-4
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
BackgroundHealthcare-associated infections (HAIs) have a major impact on public health worldwide. Particularly, hospital surfaces contaminated with bacterial pathogens are often the origin of both sporadic cases and outbreaks of HAIs. It has been demonstrated that copper surfaces reduce the microbial burden of high touch surfaces in the hospital environment. Here we report the antimicrobial characterization of a novel composite coating with embedded copper particles, named Copper Armour.MethodsThe Copper Armour bactericidal activity was evaluated in in vitro assays against several bacterial pathogens, including Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli O157:H7 and Listeria monocytogenes. Additionally, its antimicrobial properties were also evaluated in a pilot study over a nine-week period at an adult intensive care unit. For this, four high touch surfaces, including bed rails, overbed table, bedside table and IV Pole, were coated with Cooper Armour, and its microbial burden was determined over a nine-week period.ResultsCopper Armour coated samples showed an in vitro reduction in bacterial burden of >99.9% compared to control samples. Moreover, pilot study results indicate that Copper Armour significantly reduces the level of microbial contamination on high-touch surfaces in the hospital environment, as compared with standard surfaces.ConclusionsBased on its antimicrobial properties, Copper Armour is a novel self-sanitizing coating that exhibits bactericidal activity against important human pathogens and significantly reduces the microbial burden of hospital surfaces. This composite could be used as a self-sanitizing coating to complement infection control strategies in healthcare facilities.
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页数:10
相关论文
共 37 条
[1]   Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis [J].
Allegranzi, Benedetta ;
Nejad, Sepideh Bagheri ;
Combescure, Christophe ;
Graafmans, Wilco ;
Attar, Homo ;
Donaldson, Liam ;
Pittet, Didier .
LANCET, 2011, 377 (9761) :228-241
[2]   Staphylococcus aureus nosocomial infections in critically ill patients admitted in intensive care units [J].
Alvarez Lerma, Francisco ;
Palomar, Mercedes ;
Insausti, Josu ;
Olaechea, Pedro ;
Cerda, Enrique ;
Sanchez Godoy, Jose ;
de la Torre, Maria Victoria .
MEDICINA CLINICA, 2006, 126 (17) :641-646
[3]  
[Anonymous], 2014, TEST METHOD EFFICACY
[4]  
[Anonymous], 2008, Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008
[5]   Intrinsic bacterial burden associated with intensive care unit hospital beds: Effects of disinfection on population recovery and mitigation of potential infection risk [J].
Attaway, Hubert H., III ;
Fairey, Sarah ;
Steed, Lisa L. ;
Salgado, Cassandra D. ;
Michels, Harold T. ;
Schmidt, Michael G. .
AMERICAN JOURNAL OF INFECTION CONTROL, 2012, 40 (10) :907-912
[6]   Nosocomial infections after cardiac surgery in infants and children with congenital heart disease [J].
Barriga, Jose ;
Cerda, Jaime ;
Abarca, Katia ;
Ferres, Marcela ;
Fajuri, Paula ;
Riquelme, Maria ;
Carrillo, Diego ;
Claveria, Cristian .
REVISTA CHILENA DE INFECTOLOGIA, 2014, 31 (01) :16-20
[7]   Abundance and diversity of copper resistance genes cusA and copA in microbial communities in relation to the impact of copper on Chilean marine sediments [J].
Besaury, Ludovic ;
Bodilis, Josselin ;
Delgas, Fabien ;
Andrade, Santiago ;
De la Iglesia, Rodrigo ;
Ouddane, Baghdad ;
Quillet, Laurent .
MARINE POLLUTION BULLETIN, 2013, 67 (1-2) :16-25
[8]  
BRENNER F. POLA, 2003, Rev. chil. infectol., V20, P285
[9]  
Chyderiotis S, 2018, NEW INSIGHTS ANTIMIC
[10]  
Cioffi N, 2005, COPPER NANOPARTICLE, P5255