Synthesis of curacin A, an antimitotic cyclopropane-thiazoline from the marine cyanobacterium Lyngbya majuscula

被引：64

作者：

Lai, JY

Yu, JR

Mekonnen, B

Falck, JR

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT BIOCHEM,DALLAS,TX 75235

[2] UNIV TEXAS,SW MED CTR,DEPT PHARMACOL,DALLAS,TX 75235

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 40期

关键词：

D O I：

10.1016/0040-4039(96)01616-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Charette asymmetric cyclopropanation, chiral thiazoline synthesis by thioamide cyclization under modified Mitsunobu conditions, Ti(iPrO)(4)/bi-naphthol catalyzed allylstannane addition, and an exceptionally mild two-carbon homologation via dehydrative alkylation with phenylsulfonylacetonitrile/Ph(3)P/ADDP convened in an efficient, stereocontrolled route to the title bioactive heterocycle. Copyright (C) 1996 Elsevier Science Ltd

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页码：7167 / 7170

页数：4

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