Microgel assembly: Fabrication, characteristics and application in tissue engineering and regenerative medicine

被引：139
作者：
Feng, Qi [1 ,2 ,3 ]
Li, Dingguo [1 ,2 ,4 ]
Li, Qingtao [2 ,5 ]
Cao, Xiaodong [1 ,2 ,3 ]
Dong, Hua [1 ,2 ,4 ]
机构：
[1] South China Univ Technol, Sch Mat Sci & Engn, Dept Biomed Engn, Guangzhou, Peoples R China
[2] Natl Engn Res Ctr Tissue Restorat & Reconstruct N, Guangzhou, Peoples R China
[3] South China Univ Technol, Key Lab Biomed Mat & Engn, Minist Educ, Guangzhou, Peoples R China
[4] South China Univ Technol, Guangdong Prov Key Lab Biomed Engn, Guangzhou, Peoples R China
[5] South China Univ Technol, Sch Med, Guangzhou, Peoples R China
来源：
BIOACTIVE MATERIALS | 2022年 / 9卷
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Microgel assembly; Tissue engineering; Regenerative medicine; CELL; HYDROGELS; SCAFFOLDS; STRATEGIES; CHITOSAN;
D O I：
10.1016/j.bioactmat.2021.07.020
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Microgel assembly, a macroscopic aggregate formed by bottom-up assembly of micmgels, is now emerging as prospective biomaterials for applications in tissue engineering and regenerative medicine (TERM). This minireview first summarizes the fabrication strategies available for microgel assembly, including chemical reaction, physical reaction, cell-cell interaction and external driving force, then highlights its unique characteristics, such as microporosity, injectability and heterogeneity, and finally itemizes its applications in the fields of cell culture, tissue regeneration and biofabrication, especially 3D printing. The problems to be addressed for further applications of microgel assembly are also discussed.
引用
收藏
页码：105 / 119
页数：15
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