Substrate specificity:: PI(3)Kγ has it both ways

被引：5

作者：

Backer, JM ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

来源：

NATURE CELL BIOLOGY | 2005年 / 7卷 / 08期

关键词：

D O I：

10.1038/ncb0805-773

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phosphoinositide 3-kinases (PI(3)Ks) are mainly known for their lipid kinase activity in various cellular functions; however, PI(3)Ks also have protein kinase activity. Non-muscle tropomyosin has been identified as a novel protein target for PI(3)K gamma. Phosphorylation of tropomyosin is required for beta-adrenergic receptor internalization, providing new insight into PI(3)K function during clathrin-mediated endocytosis.

引用

页码：773 / 774

页数：2

共 16 条

[11] Protein kinase activity of phosphoinositide 3-kinase regulates β-adrenergic receptor endocytosis [J].

Prasad, SVN ;

Jayatilleke, A ;

Madamanchi, A ;

Rockman, HA .

NATURE CELL BIOLOGY, 2005, 7 (08) :785-U48

[12] Phosphoinositide 3-kinase regulates β2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/β-arrestin complex [J].

Prasad, SVN ;

Laporte, SA ;

Chamberlain, D ;

Caron, MG ;

Barak, L ;

Rockman, HA .

JOURNAL OF CELL BIOLOGY, 2002, 158 (03) :563-575

[13] Leukocytes navigate by compass:: roles of PI3Kγ and its lipid products [J].

Rickert, P ;

Weiner, OD ;

Wang, F ;

Bourne, HR ;

Servant, G .

TRENDS IN CELL BIOLOGY, 2000, 10 (11) :466-473

[14] Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling [J].

Shenoy, SK ;

Lefkowitz, RJ .

BIOCHEMICAL JOURNAL, 2003, 375 :503-515

[15] Autophosphorylation of p110δ phosphoinositide 3-kinase:: a new paradigm for the regulation of lipid kinases in vitro and in vivo [J].

Vanhaesebroeck, B ;

Higashi, K ;

Raven, C ;

Welham, M ;

Anderson, S ;

Brennan, P ;

Ward, SG ;

Waterfield, MD .

EMBO JOURNAL, 1999, 18 (05) :1292-1302

[16] Structural insights into phosphoinositide 3-kinase catalysis and signalling [J].

Walker, EH ;

Perisic, O ;

Ried, C ;

Stephens, L ;

Williams, RL .

NATURE, 1999, 402 (6759) :313-320

← 1 2 →