Substrate specificity:: PI(3)Kγ has it both ways

被引：5
作者：
Backer, JM [1 ]
机构：
[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
来源：
NATURE CELL BIOLOGY | 2005年 / 7卷 / 08期
关键词：
D O I：
10.1038/ncb0805-773
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Phosphoinositide 3-kinases (PI(3)Ks) are mainly known for their lipid kinase activity in various cellular functions; however, PI(3)Ks also have protein kinase activity. Non-muscle tropomyosin has been identified as a novel protein target for PI(3)K gamma. Phosphorylation of tropomyosin is required for beta-adrenergic receptor internalization, providing new insight into PI(3)K function during clathrin-mediated endocytosis.
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收藏
页码：773 / 774
页数：2
相关论文
共 16 条
[1]   Inhibition of the Arp2/3 complex-nucleated actin polymerization and branch formation by tropomyosin [J].
Blanchoin, L ;
Pollard, TD ;
Hitchcock-DeGregori, SE .
CURRENT BIOLOGY, 2001, 11 (16) :1300-1304
[2]   Bifurcation of lipid and protein kinase signals of PI3Kγ to the protein kinases PKB and MAPK [J].
Bondeva, T ;
Pirola, L ;
Bulgarelli-Leva, G ;
Rubio, I ;
Wetzker, R ;
Wymann, MP .
SCIENCE, 1998, 282 (5387) :293-296
[3]   Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms β and γ [J].
Czupalla, C ;
Culo, M ;
Müller, EC ;
Brock, C ;
Reusch, HP ;
Spicher, K ;
Krause, E ;
Nürnberg, B .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (13) :11536-11545
[4]   Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge [J].
DesMarais, V ;
Ichetovkin, I ;
Condeelis, J ;
Hitchcock-DeGregori, SE .
JOURNAL OF CELL SCIENCE, 2002, 115 (23) :4649-4660
[5]   PI-3-KINASE IS A DUAL-SPECIFICITY ENZYME - AUTOREGULATION BY AN INTRINSIC PROTEIN-SERINE KINASE-ACTIVITY [J].
DHAND, R ;
HILES, I ;
PANAYOTOU, G ;
ROCHE, S ;
FRY, MJ ;
GOUT, I ;
TOTTY, NF ;
TRUONG, O ;
VICENDO, P ;
YONEZAWA, K ;
KASUGA, M ;
COURTNEIDGE, SA ;
WATERFIELD, MD .
EMBO JOURNAL, 1994, 13 (03) :522-533
[6]   Actin assembly and endocytosis:: From yeast to mammals [J].
Engqvist-Goldstein, ÅEY ;
Drubin, DG .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2003, 19 :287-332
[7]   Tropomyosin isoforms: divining rods for actin cytoskeleton function [J].
Gunning, PW ;
Schevzov, G ;
Kee, AJ ;
Hardeman, EC .
TRENDS IN CELL BIOLOGY, 2005, 15 (06) :333-341
[8]   Phosphoinositide 3-kinase γ is an essential amplifier of mast cell function [J].
Laffargue, M ;
Calvez, R ;
Finan, P ;
Trifilieff, A ;
Barbier, M ;
Altruda, F ;
Hirsch, E ;
Wymann, MP .
IMMUNITY, 2002, 16 (03) :441-451
[9]  
LAM K, 1994, J BIOL CHEM, V269, P20648
[10]   Vertebrate tropomyosin: distribution, properties and function [J].
Perry, SV .
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 2001, 22 (01) :5-49
12