Macrolide Synthesis through Intramolecular Oxidative Cross-Coupling of Alkenes

被引：78
|
作者：
Jiang, Bing [1 ]
Zhao, Meng [1 ]
Li, Shu-Sen [1 ]
Xu, Yun-He [1 ]
Loh, Teck-Peng [1 ,2 ,3 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, iChEM Collaborat Innovat Ctr Chem Energy Mat, Hefei 230026, Anhui, Peoples R China
[2] Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Inst Adv Synth, Nanjing 210009, Jiangsu, Peoples R China
[3] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637616, Singapore
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 02期
基金：
中国国家自然科学基金;
关键词：
C-H activation; cross-coupling; homogeneous catalysis; macrocycles; rhodium; FLUORIDE-ION DETECTION; ANION RECOGNITION; LEWIS-ACID; NUCLEOPHILIC FLUORINATION; ORGANOBORON COMPOUNDS; BOND; COMPLEXES; REACTIVITY; CATALYSIS; RECEPTOR;
D O I：
10.1002/anie.201710601
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Rh-III-catalyzed intramolecular oxidative cross-coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo- and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3- conjugated diene structure.
引用
收藏
页码：555 / 559
页数：5
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