Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV

被引：82

作者：

Vergori, Alessandra ^{[1
]}

Lepri, Alessandro Cozzi ^{[2
]}

Cicalini, Stefania ^{[1
]}

Matusali, Giulia ^{[3
]}

Bordoni, Veronica ^{[4
]}

Lanini, Simone ^{[1
]}

Meschi, Silvia ^{[3
]}

Iannazzo, Roberta ^{[1
]}

Mazzotta, Valentina ^{[1
]}

Colavita, Francesca ^{[3
]}

Mastrorosa, Ilaria ^{[1
]}

Cimini, Eleonora ^{[4
]}

Mariotti, Davide ^{[4
]}

De Pascale, Lydia ^{[1
]}

Marani, Alessandra ^{[5
]}

Galli, Paola ^{[5
]}

Garbuglia, AnnaRosa ^{[3
]}

Castilletti, Concetta ^{[3
]}

Puro, Vincenzo ^{[6
]}

Agrati, Chiara ^{[4
]}

Girardi, Enrico ^{[7
]}

Vaia, Francesco ^{[5
]}

Antinori, Andrea ^{[1
]}

机构：

[1] Natl Inst Infect Dis Lazzaro Spallanzani IRCCS, HIV AIDS Unit, Rome, Italy

[2] UCL, Inst Global Hlth, Ctr Clin Res Epidemiol Modelling & Evaluat CREME, London, England

[3] Natl Inst Infect Dis LazzaroSpallanzani IRCCS, Lab Virol, Rome, Italy

[4] Natl Inst Infect Dis Lazzaro Spallanzani IRCCS, Lab Cellular Immunol & Clin Pharmacol, Rome, Italy

[5] Natl Inst Infect Dis Lazzaro Spallanzani IRCCS, Hlth Direct, Rome, Italy

[6] Natl Inst Infect Dis Lazzaro Spallanzani IRCCS, Risk Management Unit, Rome, Italy

[7] Natl Inst Infect Dis Lazzaro Spallanzani IRCCS, Sci Direct, Rome, Italy

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

关键词：

ANTIRETROVIRAL THERAPY; SARS-COV-2; INFECTION; SAFETY; INFLAMMATION; INDUCTION; COHORT;

D O I：

10.1038/s41467-022-32263-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

HIV infection may affect the immune response to vaccination. Here the authors show that humoral response in persons living with HIV after the third dose of a SARS-CoV-2 vaccine is strong and higher than that achieved with the second dose, while cell-mediated immunity remains stable. In order to investigate safety and immunogenicity of SARS-CoV-2 vaccine third dose in people living with HIV (PLWH), we analyze anti-RBD, microneutralization assay and IFN-gamma production in 216 PLWH on ART with advanced disease (CD4 count <200 cell/mm(3) and/or previous AIDS) receiving the third dose of a mRNA vaccine (BNT162b2 or mRNA-1273) after a median of 142 days from the second dose. Median age is 54 years, median CD4 nadir 45 cell/mm(3) (20-122), 93% HIV-RNA < 50 c/mL. In 68% of PLWH at least one side-effect, generally mild, is recorded. Humoral response after the third dose was strong and higher than that achieved with the second dose (>2 log(2) difference), especially when a heterologous combination with mRNA-1273 as third shot is used. In contrast, cell-mediated immunity remain stable. Our data support usefulness of third dose in PLWH currently receiving suppressive ART who presented with severe immune dysregulation.

引用

页数：13

共 53 条

[1] Coordinate Induction of Humoral and Spike Specific T-Cell Response in a Cohort of Italian Health Care Workers Receiving BNT162b2 mRNA Vaccine [J].

Agrati, Chiara ;

Castilletti, Concetta ;

Goletti, Delia ;

Meschi, Silvia ;

Sacchi, Alessandra ;

Matusali, Giulia ;

Bordoni, Veronica ;

Petrone, Linda ;

Lapa, Daniele ;

Notari, Stefania ;

Vanini, Valentina ;

Colavita, Francesca ;

Aiello, Alessandra ;

Agresta, Alessandro ;

Farroni, Chiara ;

Grassi, Germana ;

Leone, Sara ;

Vaia, Francesco ;

Capobianchi, Maria Rosaria ;

Ippolito, Giuseppe ;

Puro, Vincenzo .

MICROORGANISMS, 2021, 9 (06)

[2]

Aledo M. G., AIDS, DOI [10.1097/QAD.0000000000003161, DOI 10.1097/QAD.0000000000003161]

[3]

Alrubayyi A, 2021, NAT COMMUN, V12, DOI [10.1101/2021.02.15.431215, 10.1038/s41467-021-26137-7]

[4] Humoral and Cellular Immune Response Elicited by mRNA Vaccination Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in People Living With Human Immunodeficiency Virus Receiving Antiretroviral Therapy Based on Current CD4 T-Lymphocyte Count [J].

Antinori, Andrea ;

Cicalini, Stefania ;

Meschi, Silvia ;

Bordoni, Veronica ;

Lorenzini, Patrizia ;

Vergori, Alessandra ;

Lanini, Simone ;

De Pascale, Lidya ;

Matusali, Giulia ;

Mariotti, Davide ;

Lepri, Alessandro Cozzi ;

Galli, Paola ;

Pinnetti, Carmela ;

Gagliardini, Roberta ;

Mazzotta, Valentina ;

Mastrorosa, Ilaria ;

Grisetti, Susanna ;

Colavita, Francesca ;

Cimini, Eleonora ;

Grilli, Elisabetta ;

Bellagamba, Rita ;

Lapa, Daniele ;

Sacchi, Alessandra ;

Marani, Alessandra ;

Cerini, Carlo ;

Candela, Caterina ;

Fusto, Marisa ;

Puro, Vincenzo ;

Castilletti, Concetta ;

Agrati, Chiara ;

Girardi, Enrico ;

Vaia, Francesco .

CLINICAL INFECTIOUS DISEASES, 2022, 75 (01) :E552-E563

[5] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[6] Humoral response to mRNA anti-COVID-19 vaccines BNT162b2 and mRNA-1273 in patients with chronic lymphocytic leukemia [J].

Bagacean, Cristina ;

Letestu, Remi ;

Al-Nawakil, Chadi ;

Brichler, Segolene ;

Levy, Vincent ;

Sritharan, Nanthara ;

Delmer, Alain ;

Dartigeas, Caroline ;

Leblond, Veronique ;

Roos-Weil, Damien ;

Tomowiak, Cecile ;

Merabet, Fatiha ;

Bene, Marie C. ;

Clavert, Aline ;

Chaoui, Driss ;

Genet, Philippe ;

Guieze, Romain ;

Laribi, Kamel ;

Drenou, Bernard ;

Willems, Lise ;

Puppinck, Christian ;

Legendre, Hugo ;

Troussard, Xavier ;

Malartre, Stephanie ;

Cymbalista, Florence ;

Michallet, Anne-Sophie .

BLOOD ADVANCES, 2022, 6 (01) :207-211

[7] Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant [J].

Bernal, Jamie Lopez ;

Andrews, Nick ;

Gower, Charlotte ;

Gallagher, Eileen ;

Simmons, Ruth ;

Thelwall, Simon ;

Stowe, Julia ;

Tessier, Elise ;

Groves, Natalie ;

Dabrera, Gavin ;

Myers, Richard ;

Campbell, Colin N. J. ;

Amirthalingam, Gayatri ;

Edmunds, Matt ;

Zambon, Maria ;

Brown, Kevin E. ;

Hopkins, Susan ;

Chand, Meera ;

Ramsay, Mary .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (07) :585-594

[8] HIV infection and COVID-19 death: a population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform [J].

Bhaskaran, Krishnan ;

Rentsch, Christopher T. ;

MacKenna, Brian ;

Schultze, Anna ;

Mehrkar, Amir ;

Bates, Chris J. ;

Eggo, Rosalind M. ;

Morton, Caroline E. ;

Bacon, Sebastian C. J. ;

Inglesby, Peter ;

Doughlas, Ian J. ;

Walker, Alex J. ;

McDonald, Helen, I ;

Cockburn, Jonathan ;

Williamson, Elizabeth J. ;

Evans, David ;

Forbes, Harriet J. ;

Curtis, Helen J. ;

Hulme, William J. ;

Parry, John ;

Hester, Frank ;

Harper, Sam ;

Evans, Stephen J. W. ;

Smeeth, Liam ;

Goldacre, Ben .

LANCET HIV, 2021, 8 (01) :e24-e32

[9]

Brumme Z. L., PREPRINT

[10] Effects of Acute and Chronic Inflammation on B-Cell Development and Differentiation [J].

Cain, Derek ;

Kondo, Motonari ;

Chen, Huaiyong ;

Kelsoe, Garnett .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (02) :266-277

← 1 2 3 4 5 6 →