Transmission Clustering Drives the Onward Spread of the HIV Epidemic Among Men Who Have Sex With Men in Quebec

被引：96

作者：

Brenner, Bluma G. ^{[1
]}

Roger, Michel ^{[2
,3
]}

Stephens, David ^{[4
]}

Moisi, Daniela ^{[1
]}

Hardy, Isabelle ^{[2
,3
]}

Weinberg, Jonathan ^{[4
]}

Turgel, Reuven ^{[1
]}

Charest, Hugues ^{[5
]}

Koopman, James ^{[6
]}

Wainberg, Mark A. ^{[1
]}

机构：

[1] McGill Univ, Jewish Gen Hosp, AIDS Ctr, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

[2] Univ Montreal, Dept Microbiol & Immunol, Montreal, PQ H3C 3J7, Canada

[3] Univ Montreal, Ctr Hosp, Ctr Rech, Montreal, PQ, Canada

[4] McGill Univ, Dept Math & Stat, Montreal, PQ H3T 1E2, Canada

[5] Inst Sante Publ Quebec, Quebec City, PQ, Canada

[6] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 204卷 / 07期

基金：

美国国家卫生研究院;

关键词：

PERSONS AWARE; UNITED-STATES; INFECTION; DETERMINANTS; POPULATION; NETWORKS; UNAWARE;

D O I：

10.1093/infdis/jir468

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Phylodynamic analysis and epidemiologic data identified 3 patterns of spread of primary human immunodeficiency virus type 1 infection (PHI) among men who have sex with men (2001-2009): 420 unique PHIs, 102 small clusters (2-4 PHIs per cluster, n = 280), and 46 large clusters (5-31 PHIs per cluster, n 5 450). Large clusters disproportionately increased from 25.2% of PHIs in 2005 to 39.1% in 2009 (chi(2) = 33.9, P < .001). Scalar expansion of large clusters over 11 months (interquartile range, 3.5-25.5 months) correlated with cluster membership size (r(2) = 0.174, F = 4.424, P = .047). PHI cohort data revealed variations in social networks and risk behaviors among the 3 groups, suggesting the need for tailored prevention measures.

引用

页码：1115 / 1119

页数：5

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