Synthesis of mono- and N,N-disubstituted ureas

被引：21

作者：

Katritzky, AR ^{[1
]}

Kirichenko, N ^{[1
]}

Rogovoy, BV ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

来源：

ARKIVOC | 2003年

关键词：

urea; preparation; benzotriazole; substitution; solid-phase synthesis;

D O I：

10.3998/ark.5550190.0004.802

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzotriazole-1-carboxamide is a new efficient reagent for the preparation of mono- and N,N-disubstituted ureas. The title ureas 3 were obtained from benzotriazole-1-carboxamide with primary and secondary aliphatic amines and p-anisidine under mild conditions with simple purification in isolated yields of 61-96%. The procedure developed is suitable for solid-phase work.

引用

页码：8 / 14

页数：7

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