Genetic variation of the HIV-1 integrase region in newly diagnosed anti-retroviral drug-naive patients with HIV/AIDS in Korea

被引:10
作者
Kim, J-Y. [1 ,2 ]
Kim, E-J. [1 ]
Choi, J-Y. [1 ]
Kwon, O-K. [1 ]
Kim, G. J. [1 ]
Choi, S. Y. [2 ]
Kim, S. S. [1 ]
机构
[1] Natl Inst Hlth, Dept Pathol & Immunol, Div Aids, Seoul, South Korea
[2] Korea Univ, Grad Sch Biotechnol, Seoul, South Korea
关键词
Genetic variation; HIV-1; integrase inhibitor; polymorphism; resistant mutation; RESISTANCE;
D O I
10.1111/j.1469-0691.2010.03392.x
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The survival time of HIV/AIDS patients in Korea has increased since HAART (highly active anti-retroviral therapy) was introduced. However, the occurrence of drug-resistant strains requires new anti-retroviral drugs, one of which, an integrase inhibitor (INI), was approved by the US Food and Drug Administration (FDA) in 2007. INIs have been used for therapy in many countries and are about to be employed in Korea. Therefore, it is important to identify basic mutant variants prior to the introduction of INIs in order to estimate their efficacy. To monitor potential drug-resistant INI mutations in Korean HIV/AIDS patients, the polymorphism of the int gene was investigated together with the pol gene using a genotypic assay for 75 randomly selected Korean HIV-1 patients newly diagnosed in 2007. The drug-resistant mutation sequences were analysed using the Stanford HIV DB and the International AIDS Society resistance testing-USA panel (IAS-USA). Seventy strains of Korean subtype B were compared with foreign subtype-B strains, and there were no significantly different variants of the int gene region in the study population. Major mutation sites in the integrase (E92Q, F121Y, G140A/S, Y143C/R, Q148H/R/K and N155H) were not detected, and only a few minor mutation sites (L74M, V151I, E157Q, V165I, I203M, S230N and D232N) were identified in 21 strains (28%). Resistance due to mutations in the pol gene was observed in a single strain (1.3%) resistant to protease inhibitors (PIs) and in four strains (5.3%) resistant to reverse transcriptase inhibitors (RTIs). In summary, this demonstrates that INIs will be susceptible to drug naive HIV/AIDS patients in Korea.
引用
收藏
页码:1155 / 1159
页数:5
相关论文
共 50 条
[41]   Pretreatment HIV-1 Drug Resistance Among Newly Diagnosed People in Eastern Ethiopia [J].
Gemechu, Abdella ;
Mihret, Adane ;
Mengesha, Mesfin ;
Alemayehu, Dawit Hailu ;
Kidane, Eleni ;
Aseffa, Abraham ;
Howe, Rawleigh ;
Seyoum, Berhanu ;
Mulu, Andargachew .
HEALTH SCIENCE REPORTS, 2025, 8 (04)
[42]   Transmitted drug resistance and type of infection in newly diagnosed HIV-1 individuals in Honduras [J].
Murillo, Wendy ;
Paz-Bailey, Gabriela ;
Morales, Sonia ;
Monterroso, Edgar ;
Paredes, Mayte ;
Dobbs, Trudy ;
Parekh, Bharat S. ;
Albert, Jan ;
de Rivera, Ivette Lorenzana .
JOURNAL OF CLINICAL VIROLOGY, 2010, 49 (04) :239-244
[43]   Transmitted drug resistance in newly diagnosed and treatment-naive HIV type 1-infected patients in Hungary [J].
Ay, Eva ;
Mueller, Viktor ;
Mezei, Maria ;
Pocskay, Agnes ;
Koroknai, Anita ;
Mueller, Dalma ;
Gyori, Zoltan ;
Marschalko, Marta ;
Toth, Bela ;
Karpati, Sarolta ;
Lakatos, Botond ;
Szlavik, Janos ;
Takacs, Maria ;
Minarovits, Janos .
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2020, 20 :124-130
[44]   Immune responses and reconstitution in HIV-1 infected individuals: impact of anti-retroviral therapy, cytokines and therapeutic vaccination [J].
Imami, N ;
Hardy, G ;
Burton, C ;
Pires, A ;
Pido-Lopez, J ;
Moss, R ;
Gazzard, B ;
Gotch, F .
IMMUNOLOGY LETTERS, 2001, 79 (1-2) :63-76
[45]   Moderate rate of transmitted resistance mutations to antiretrovirals and genetic diversity in newly HIV-1 patients diagnosed in Benin [J].
Edmond Tchiakpe ;
Rene K. Keke ;
Nicole Vidal ;
Clément Ahoussinou ;
Olga Sekpe ;
Hermione G. Dagba ;
Eric Gbaguidi ;
Conrad Tonoukouen ;
Aldric Afangnihoun ;
Moussa Bachabi ;
Flore A. Gangbo ;
Halimatou Diop-Ndiaye ;
Coumba Toure-Kane .
BMC Research Notes, 13
[46]   Moderate rate of transmitted resistance mutations to antiretrovirals and genetic diversity in newly HIV-1 patients diagnosed in Benin [J].
Tchiakpe, Edmond ;
Keke, Rene K. ;
Vidal, Nicole ;
Ahoussinou, Clement ;
Sekpe, Olga ;
Dagba, Hermione G. ;
Gbaguidi, Eric ;
Tonoukouen, Conrad ;
Afangnihoun, Aldric ;
Bachabi, Moussa ;
Gangbo, Flore A. ;
Diop-Ndiaye, Halimatou ;
Toure-Kane, Coumba .
BMC RESEARCH NOTES, 2020, 13 (01)
[47]   Stochastic modelling of the eradication of the HIV-1 infection by stimulation of latently infected cells in patients under highly active anti-retroviral therapy [J].
Daniel Sánchez-Taltavull ;
Arturo Vieiro ;
Tomás Alarcón .
Journal of Mathematical Biology, 2016, 73 :919-946
[48]   Stochastic modelling of the eradication of the HIV-1 infection by stimulation of latently infected cells in patients under highly active anti-retroviral therapy [J].
Sanchez-Taltavull, Daniel ;
Vieiro, Arturo ;
Alarcon, Tomas .
JOURNAL OF MATHEMATICAL BIOLOGY, 2016, 73 (04) :919-946
[49]   Antiretroviral drug resistance in HIV-1 therapy-naive patients in Cuba [J].
Perez, Lissette ;
Kouri, Vivian ;
Aleman, Yoan ;
Abrahantes, Yeisel ;
Correa, Consuelo ;
Aragones, Carlos ;
Martinez, Orlando ;
Perez, Jorge ;
Fonseca, Carlos ;
Campos, Jorge ;
Alvarez, Delmis ;
Schrooten, Yoeri ;
Dekeersmaeker, Nathalie ;
Imbrechts, Stijn ;
Beheydt, Gertjan ;
Vinken, Lore ;
Soto, Yudira ;
Alvarez, Alina ;
Vandamme, Anne-Mieke ;
Van Laethem, Kristel .
INFECTION GENETICS AND EVOLUTION, 2013, 16 :144-150
[50]   Epidemiology of drug-resistant HIV-1 transmission in naive patients in Spain [J].
Yebra, Gonzalo ;
Holguin, Africa .
MEDICINA CLINICA, 2010, 135 (12) :561-567