A one-step approach to the highly efficient preparation of core-stabilized polymeric micelles with a mixed shell formed by two incompatible polymers

被引:61
作者
Hui, TR
Chen, DY [1 ]
Jiang, M
机构
[1] Fudan Univ, Dept Macromol Sci, Shanghai 200433, Peoples R China
[2] Fudan Univ, Key Lab Mol Engn & Polymers, Shanghai 200433, Peoples R China
关键词
D O I
10.1021/ma050435c
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The preparation of core-stabilized polymeric micelles with a mixed shell (PMMS) formed by two incompatible polymers was discussed. The PMMS were prepared by micellization of an A-b, B-b-C triblock copolymer or a diblock copolymer. A one step approach to the core-stabilized PMMS with PEO/PS as the shell by direct cross-linking P2VP in PS-b-P2VP and PEO-b-P2VP, which was the common solvent of the block copolymers. The weight ratio of PS-b-P2VP/PEG-b-P2VP in the solutions was fixed at 1/1.
引用
收藏
页码:5834 / 5837
页数:4
相关论文
共 28 条
[11]   Block copolymer micelles for drug delivery: design, characterization and biological significance [J].
Kataoka, K ;
Harada, A ;
Nagasaki, Y .
ADVANCED DRUG DELIVERY REVIEWS, 2001, 47 (01) :113-131
[12]   Phosphorylcholine-polycation diblock copolymers as synthetic vectors for gene delivery [J].
Lam, JKW ;
Ma, Y ;
Armes, SP ;
Lewis, AL ;
Baldwin, T ;
Stolnik, S .
JOURNAL OF CONTROLLED RELEASE, 2004, 100 (02) :293-312
[13]   Hybrid block copolymer micelles with partly hydrophobically modified polyelectrolyte shells in polar and aqueous media:: Experimental study using fluorescence correlation spectroscopy, time-resolved fluorescence, light scattering, and atomic force microscopy [J].
Matejícek, P ;
Humpolícková, J ;
Procházka, K ;
Tuzar, Z ;
Spírková, M ;
Hof, M ;
Webber, SE .
JOURNAL OF PHYSICAL CHEMISTRY B, 2003, 107 (32) :8232-8240
[14]   Polymer nanocapsules [J].
Meier, W .
CHEMICAL SOCIETY REVIEWS, 2000, 29 (05) :295-303
[15]   Shell cross-linked nanoparticles designed to target angiogenic blood vessels via αvβ3 receptor-ligand interactions [J].
Pan, DJ ;
Turner, JL ;
Wooley, KL .
MACROMOLECULES, 2004, 37 (19) :7109-7115
[16]   Hybrid polymeric micelles with hydrophobic cores and mixed polyelectrolyte/nonelectrolyte shells in aqueous media.: 2.: Studies of the shell behavior [J].
Podhájecká, K ;
Stepánek, M ;
Procházka, K ;
Brown, W .
LANGMUIR, 2001, 17 (14) :4245-4250
[17]   Onion-type micelles in aqueous media [J].
Prochazka, K ;
Martin, TJ ;
Webber, SE ;
Munk, P .
MACROMOLECULES, 1996, 29 (20) :6526-6530
[18]   Micellar nanocontainers distribute to defined cytoplasmic organelles [J].
Savic, R ;
Luo, LB ;
Eisenberg, A ;
Maysinger, D .
SCIENCE, 2003, 300 (5619) :615-618
[19]   Hybrid polymeric micelles with hydrophobic cores and mixed polyelectrolyte/nonelectrolyte shells in aqueous media.: 1.: Preparation and basic characterization [J].
Stepánek, M ;
Podhájecká, K ;
Tesarová, E ;
Procházka, K ;
Tuzar, Z ;
Brown, W .
LANGMUIR, 2001, 17 (14) :4240-4244
[20]   RUTHENIUM TETRAOXIDE STAINING OF POLYMERS FOR ELECTRON-MICROSCOPY [J].
TRENT, JS ;
SCHEINBEIM, JI ;
COUCHMAN, PR .
MACROMOLECULES, 1983, 16 (04) :589-598