The NKT cell system: bridging innate and acquired immunity

被引：195

作者：

Taniguchi, M ^{[1
]}

Seino, K

Nakayama, T

机构：

[1] RIKEN, Res Ctr Allergy & Immunol, Lab Immunoregulat, Yokohama, Kanagawa, Japan

[2] Chiba Univ, Grad Sch Med, Dept Mol Immunol, Chiba, Japan

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 12期

关键词：

D O I：

10.1038/ni1203-1164

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although natural killer T cells are activated during infection, it is not clear how this process occurs. Closer examination indicates that recognition of endogenous ligands and interleukin 12, rather than bacterial products, may drive the activation process.

引用

页码：1164 / 1165

页数：3

共 11 条

[1] Mechanism of CD1d-restricted natural killer T cell activation during microbial infection [J].

Brigl, M ;

Bry, L ;

Kent, SC ;

Gumperz, JE ;

Brenner, MB .

NATURE IMMUNOLOGY, 2003, 4 (12) :1230-1237

[2] Requirement for V(alpha)14 NKT cells in IL-12-mediated rejection of tumors [J].

Cui, JQ ;

Shin, T ;

Kawano, T ;

Sato, H ;

Kondo, E ;

Toura, I ;

Kaneko, Y ;

Koseki, H ;

Kanno, M ;

Taniguchi, M .

SCIENCE, 1997, 278 (5343) :1623-1626

[3] Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice [J].

Hong, SM ;

Scherer, DC ;

Singh, N ;

Mendiratta, SK ;

Serizawa, I ;

Koezuka, Y ;

Van Kaer, L .

IMMUNOLOGICAL REVIEWS, 1999, 169 :31-44

[4] CD1d-restricted and TCR-mediated activation of V(alpha)14 NKT cells by glycosylceramides [J].

Kawano, T ;

Cui, JQ ;

Koezuka, Y ;

Toura, I ;

Kaneko, Y ;

Motoki, K ;

Ueno, H ;

Nakagawa, R ;

Sato, H ;

Kondo, E ;

Koseki, H ;

Taniguchi, M .

SCIENCE, 1997, 278 (5343) :1626-1629

[5] The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells [J].

Kitamura, H ;

Iwakabe, K ;

Yahata, T ;

Nishimura, S ;

Ohta, A ;

Ohmi, Y ;

Sato, M ;

Takeda, K ;

Okumura, K ;

van Kaer, L ;

Kawano, T ;

Taniguchi, M ;

Nishimura, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (07) :1121-1127

[6] CD1 molecules and CD1-dependent T cells in bacterial infections: a link from innate to acquired immunity? [J].

Schaible, UE ;

Kaufmann, SHE .

SEMINARS IN IMMUNOLOGY, 2000, 12 (06) :527-535

[7] Differential tumor surveillance by natural killer (NK) and NKT cells [J].

Smyth, MJ ;

Thia, KYT ;

Street, SEA ;

Cretney, E ;

Trapani, JA ;

Taniguchi, M ;

Kawano, T ;

Pelikan, SB ;

Crowe, NY ;

Godfrey, DI .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (04) :661-668

[8] A fresh look at tumor immunosurveillance and immunotherapy [J].

Smyth, MJ ;

Godfrey, DI ;

Trapani, JA .

NATURE IMMUNOLOGY, 2001, 2 (04) :293-299

[9] Toll-like receptors [J].

Takeda, K ;

Kaisho, T ;

Akira, S .

ANNUAL REVIEW OF IMMUNOLOGY, 2003, 21 :335-376

[10] The regulatory role of Vα14 NKT cells in innate and acquired immune response [J].

Taniguchi, M ;

Harada, M ;

Kojo, S ;

Nakayama, T ;

Wakao, H .

ANNUAL REVIEW OF IMMUNOLOGY, 2003, 21 :483-513

← 1 2 →