Anticancer Effects of Resveratrol-Loaded Solid Lipid Nanoparticles on Human Breast Cancer Cells

被引：89

作者：

Wang, Wenrui ^{[1
]}

Zhang, Lingyu ^{[2
]}

Chen, Tiantian ^{[2
]}

Guo, Wen ^{[1
]}

Bao, Xunxia ^{[1
]}

Wang, Dandan ^{[1
]}

Ren, Baihui ^{[1
]}

Wang, Haifeng ^{[2
]}

Li, Yu ^{[2
]}

Wang, Yueyue ^{[2
]}

Chen, Sulian ^{[3
]}

Tang, Baoding ^{[4
]}

Yang, Qingling ^{[3
]}

Chen, Changjie ^{[3
]}

机构：

[1] Bengbu Med Coll, Dept Biotechnol, Bengbu 233030, Anhui, Peoples R China

[2] Bengbu Med Coll, Clin Testing & Diagnose Expt Ctr, Bengbu 233030, Anhui, Peoples R China

[3] Bengbu Med Coll, Dept Biochem & Mol Biol, Bengbu 233030, Anhui, Peoples R China

[4] Bengbu Med Coll, Dept Oncol, Bengbu 233030, Anhui, Peoples R China

来源：

MOLECULES | 2017年 / 22卷 / 11期

关键词：

solid lipid nanoparticle; resveratrol; breast cancer; cyclinD1; ORAL BIOAVAILABILITY; DELIVERY; ANTIOXIDANT;

D O I：

10.3390/molecules22111814

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, resveratrol-loaded solid lipid nanoparticles (Res-SLNs) were successfully designed to treat MDA-MB-231 cells. The Res-SLNs were prepared using emulsification and low-temperature solidification method. The Res-SLNs were spherical, with small size, negative charge, and narrow size distribution. Compared with free resveratrol, the Res-SLNs displayed a superior ability in inhibiting the proliferation of MDA-MB-231 cells. In addition, Res-SLNs exhibited much stronger inhibitory effects on the invasion and migration of MDA-MB-231 cells. Western blot analysis revealed that Res-SLNs could promote the ratio of Bax/Bcl-2 but decreased the expression of cyclinD1 and c-Myc. These results indicate that the Res-SLN may have great potential for breast cancer treatment.

引用

页数：11

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