Disulfiram in glioma: Literature review of drug repurposing

被引：7
作者：
Zhong, Shiyu [1 ]
Liu, Shengyu [1 ]
Shi, Xin [2 ,3 ]
Zhang, Xudong [1 ]
Li, Kunhang [1 ]
Liu, Guojun [1 ]
Li, Lishuai [1 ]
Tao, Shanwei [4 ]
Zheng, Bowen [1 ]
Sheng, Weichen [1 ]
Ye, Ziyin [1 ]
Xing, Qichen [1 ]
Zhai, Qingqing [5 ]
Ren, Lijie [6 ]
Wu, Ying [7 ]
Bao, Yijun [1 ]
机构：
[1] China Med Univ, Dept Neurosurg, Fourth Hosp, Shenyang, Peoples R China
[2] Shandong Technol & Business Univ, Sch Math & Informat Sci, Yantai, Peoples R China
[3] Manchester Metropolitan Univ, Business Sch, All St Campus, Manchester, England
[4] Zhengzhou Univ, Luoyang Cent Hosp, Luoyang, Peoples R China
[5] Shanghai Univ, Sch Management, Shanghai, Peoples R China
[6] Shenzhen Univ, Neurol Dept, Shenzhen Second Peoples Hosp, Affiliated Hosp 1,Hlth Sci Ctr, Shenzhen, Peoples R China
[7] China Med Univ, First Hosp, Dept Gen Practice, Shenyang, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷
基金：
美国国家科学基金会;
关键词：
gliomas; glioblastoma multiforme; disulfiram; drug repurposing; temozolomide; O-6-METHYLGUANINE-DNA METHYLTRANSFERASE MGMT; GLIOBLASTOMA STEM-CELLS; PANCREATIC-CANCER CELLS; CENTRAL-NERVOUS-SYSTEM; KAPPA-B ACTIVITY; BREAST-CANCER; ALDEHYDE DEHYDROGENASE; IN-VITRO; PHASE-I; ADJUVANT TEMOZOLOMIDE;
D O I：
10.3389/fphar.2022.933655
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Gliomas are the most common malignant brain tumors. High-grade gliomas, represented by glioblastoma multiforme (GBM), have a poor prognosis and are prone to recurrence. The standard treatment strategy is tumor removal combined with radiotherapy and chemotherapy, such as temozolomide (TMZ). However, even after conventional treatment, they still have a high recurrence rate, resulting in an increasing demand for effective anti-glioma drugs. Drug repurposing is a method of reusing drugs that have already been widely approved for new indication. It has the advantages of reduced research cost, safety, and increased efficiency. Disulfiram (DSF), originally approved for alcohol dependence, has been repurposed for adjuvant chemotherapy in glioma. This article reviews the drug repurposing method and the progress of research on disulfiram reuse for glioma treatment.
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页数：15
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