Neuroprotective Effect of Matrine in Mouse Model of Vincristine-Induced Neuropathic Pain

被引:60
作者
Gong, Shuai-Shuai [1 ]
Li, Yu-Xiang [2 ]
Zhang, Meng-Ting [1 ]
Du, Juan [1 ]
Ma, Peng-Sheng [1 ]
Yao, Wan-Xia [1 ]
Zhou, Ru [1 ]
Niu, Yang [3 ]
Sun, Tao [4 ]
Yu, Jian-Qiang [1 ,5 ,6 ]
机构
[1] Ningxia Med Univ, Dept Pharmacol, Coll Pharm, 1160 Shengli St, Yinchuan 750004, Ningxia Hui Aut, Peoples R China
[2] Ningxia Med Univ, Coll Nursing, Yinchuan 750004, Peoples R China
[3] Ningxia Med Univ, Key Lab Hui Ethn Med Modernizat, Minist Educ, Yinchuan 750004, Peoples R China
[4] Ningxia Med Univ, Ningxia Key Lab Craniocerebral Dis Ningxia Hui Au, Yinchuan 750004, Peoples R China
[5] Ningxia Med Univ, Ningxia Hui Med Modern Engn Res Ctr, Yinchuan 750004, Peoples R China
[6] Ningxia Med Univ, Collaborat Innovat Ctr, Yinchuan 750004, Peoples R China
基金
中国国家自然科学基金;
关键词
Neuropathic pain; Matrine; Vincristine; Neuroprotective; Electrophysiology; Anti-inflammatory; CHRONIC CONSTRICTION INJURY; ACUTE LYMPHOBLASTIC-LEUKEMIA; PERIPHERAL NEUROPATHY; RAT MODEL; ANTIINFLAMMATORY CYTOKINE; MECHANICAL ALLODYNIA; INHIBITING APOPTOSIS; ANIMAL-MODEL; MICE; ANTIOXIDANT;
D O I
10.1007/s11064-016-2040-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Chemotherapy drugs such as vincristine (VCR) can cause neuropathic pain, and there is still lack of ideal strategy to treat it. The current study was designed to investigate effect of matrine (MT) on VCR-induced neuropathic pain in animal model. VCR (75 mu g/kg, i.p. for 10 consecutive days) was administered to induce painful neuropathy model in mice. MT (15, 30 and 60 mg/kg, i.p.) and pregabalin (10 mg/kg, i.p.) were administered for 11 consecutive days. Various tests were performed to assess the degree of pain at different days (1, 6, 11, 16, and 21). Von Frey hair, hot plate, cold-plate and paw pressure tests were conducted to assess the degree of mechanical allodynia, thermal hyperalgesia, cold allodynia and mechanical hyperalgesia in the hind paw respectively. The electrophysiological and histopathological changes were also analyzed. Furthermore, tissue malondialdehyde (MDA), total antioxidant capacity (T-AOC),superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total calcium (TCA), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10) were measured to investigate possible involvement of MT in inflammation and oxidative stress. Administration of MT attenuated the VCR-induced behavioral alterations as well as electrophysiological and histopathological changes in a dose dependent manner. Further, MT also attenuated the VCR-induced oxidative stress (MDA, T-AOC, GSH-Px, SOD and TCA) and inflammation (MPO, TNF-alpha, IL-6 and IL-10). Taken together, MT ameliorated VCR-induced painful neuropathy, which might be attributed to neuroprotective effects by subsequent reduction in oxidative stress and anti-inflammatory actions.
引用
收藏
页码:3147 / 3159
页数:13
相关论文
共 50 条
[41]   Neuroprotective Effect of Anethole Against Neuropathic Pain Induced by Chronic Constriction Injury of the Sciatic Nerve in Mice [J].
Wang, Bing ;
Zhang, Guoxin ;
Yang, Mei ;
Liu, Ning ;
Li, Yu-Xiang ;
Ma, Hanxiang ;
Ma, Lin ;
Sun, Tao ;
Tan, Huanran ;
Yu, Jianqiang .
NEUROCHEMICAL RESEARCH, 2018, 43 (12) :2404-2422
[42]   Vincristine-induced alterations in Schwann cells of mouse peripheral nerve [J].
Djaldetti, R ;
Hart, J ;
Alexandrova, S ;
Cohen, S ;
Beilin, BZ ;
Djaldetti, M ;
Bessler, H .
AMERICAN JOURNAL OF HEMATOLOGY, 1996, 52 (04) :254-257
[43]   MiR-30d Participates in Vincristine-Induced Neuropathic Pain by Down-Regulating GAD67 [J].
Han Wang ;
Yang Sun ;
Yu Wu ;
Yi-Jia Shen ;
Jun Xia ;
Ye-Hao Xu ;
Liang Yue ;
Li Sun ;
Xiu-Juan Li ;
Yu Ma ;
Yuan-Chang Xiong ;
Dai Li .
Neurochemical Research, 2022, 47 :481-492
[44]   Ameliorative effect of Vernonia cinerea in vincristine-induced painful neuropathy in rats [J].
Thiagarajan, Venkata Rathina Kumar ;
Shanmugam, Palanichamy ;
Krishnan, Uma Maheswari ;
Muthuraman, Arunachalam .
TOXICOLOGY AND INDUSTRIAL HEALTH, 2014, 30 (09) :794-805
[45]   MiR-30d Participates in Vincristine-Induced Neuropathic Pain by Down-Regulating GAD67 [J].
Wang, Han ;
Sun, Yang ;
Wu, Yu ;
Shen, Yi-Jia ;
Xia, Jun ;
Xu, Ye-Hao ;
Yue, Liang ;
Sun, Li ;
Li, Xiu-Juan ;
Ma, Yu ;
Xiong, Yuan-Chang ;
Li, Dai .
NEUROCHEMICAL RESEARCH, 2022, 47 (02) :481-492
[46]   Neuroprotective mechanism of Ajugarin-I against Vincristine-Induced neuropathic pain via regulation of Nrf2/NF-?B and Bcl2 signalling [J].
Khan, Adnan ;
Shal, Bushra ;
Khan, Ashraf Ullah ;
Shah, Kifayat Ullah ;
Zahra, Syeda Saniya ;
ul Haq, Ihsan ;
Din, Fakhar ud ;
Ali, Hussain ;
Khan, Salman .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 118
[47]   Minocycline Prevents the Development of Mechanical Allodynia in Mouse Models of Vincristine-Induced Peripheral Neuropathy [J].
Starobova, H. ;
Mueller, A. ;
Allavena, R. ;
Lohman, R. J. ;
Sweet, M. J. ;
Vetter, I .
FRONTIERS IN NEUROSCIENCE, 2019, 13
[48]   Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3α-reduced neurosteroids [J].
Aouad, Maya ;
Charlet, Alexandre ;
Rodeau, Jean-Luc ;
Poisbeau, Pierrick .
PAIN, 2009, 147 (1-3) :54-59
[49]   Suppressive Effect of Imipramine on Vincristine-Induced Mechanical Allodynia in Mice [J].
Saika, Fumihiro ;
Kiguchi, Norikazu ;
Kobayashi, Yuka ;
Fukazawa, Yohji ;
Maeda, Takehiko ;
Ozaki, Masanobu ;
Kishioka, Shiroh .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2009, 32 (07) :1231-1234
[50]   Attenuation of vincristine-induced neuropathy by synthetic cyclohexenone-functionalized derivative in mice model [J].
Jawad Khan ;
Gowhar Ali ;
Rasool Khan ;
Rahim Ullah ;
Salim Ullah .
Neurological Sciences, 2019, 40 :1799-1811