Hydrodynamic analysis of pancreatic islet micro-encapsulation by selective withdrawal

被引：8
|
作者：
Hatziavramidis, D. [2 ]
Pozrikidis, C. [1 ]
机构：
[1] Univ Calif San Diego, Dept Mech & Aerosp Engn, La Jolla, CA 92093 USA
[2] IIT, Dept Chem Engn, Chicago, IL 60616 USA
来源：
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS | 2008年 / 32卷 / 01期
基金：
美国国家科学基金会;
关键词：
stokes flow; boundary element method; interfacial flow;
D O I：
10.1016/j.enganabound.2007.07.001
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
A hydrodynamic analysis of a selective-withdrawal process Suitable for the micro-encapsulation of pancreatic islets is presented. In the micro-encapsulation device, a feeding system located on the upper side of a water-oil interface dispenses individual cells or cell aggregates in a single file by hydrodynamic focusing, while a valveless, diffuser-nozzle micro-pump located on the lower side of the interface removes the encapsulated islets for further processing. The apparatus ensures the separate encapsulation of the individual islets by a Structurally stable, semi-permeable, controlled thickness membrane. In the theoretical model, the feed nozzle is modeled as a point source and the removal nozzle is modeled as a point sink. Small and large deformations of the interface are considered by analytical and boundary element methods, and critical conditions for selective withdrawal are established. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：11 / 20
页数：10
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