Synthesis & biological activity of some 2-substituted-amino-3-(N-o-tolylcarboxamido)-4,5-dimethylthiophenes

被引：0
作者：
Raju, VS [1 ]
Mohan, S
Saravanan, J
机构：
[1] Al Ameen Coll Pharm, Dept Pharmaceut Chem, Bangalore 560027, Karnataka, India
[2] MS Ramaiah Coll Pharm, Gokula Extn, Bangalore 560054, Karnataka, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 1998年 / 8卷 / 01期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Some new 2-substituted-amino-3-(N-o-tolytcarboxamido)-4,5-dimethylthiophenes were synthesized by reacting 3-N-o-tolylcarboxamido-2-(omega-chloro acetamido)-4,5-dimethyl thiophene (IIIa) with different primary and secondary amines. These compounds were characterized by their elemental analysis and spectral data. Some of them were found to have significant analgesic and antiinflammatory activities.
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页码：59 / 62
页数：4
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