Large volume leukapheresis: Efficacy and safety of processing patient's total blood volume six times

被引：23

作者：

Bojanic, Ines ^{[1
]}

Dubravcic, Klara ^{[2
]}

Batinic, Drago ^{[2
]}

Cepulic, Branka Golubic ^{[1
]}

Mazic, Sanja ^{[1
]}

Hren, Darko ^{[3
]}

Nemet, Damir ^{[4
]}

Labar, Boris ^{[4
]}

机构：

[1] Univ Hosp Ctr Zagreb, Dept Transfus Med & Cellular Therapy, Zagreb 10000, Croatia

[2] Univ Hosp Ctr Zagreb, Dept Immunol, Zagreb 10000, Croatia

[3] Univ Split, Fac Philosophy, Zajceva Bb, Split, Croatia

[4] Univ Hosp Ctr Zagreb, Dept Internal Med, Zagreb 10000, Croatia

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2011年 / 44卷 / 02期

关键词：

STEM-CELL COLLECTION; COLONY-FORMING-UNITS; PROGENITOR CELLS; GRANULOCYTE-MACROPHAGE; MULTIPLE-MYELOMA; CROSSOVER TRIAL; CD34(+) CELLS; HEMATOPOIETIC PROGENITORS; PEDIATRIC-PATIENTS; APHERESIS;

D O I：

10.1016/j.transci.2011.01.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Large-volume leukapheresis (LVL) differs from standard leukapheresis by increased blood flow and an altered anticoagulation regimen. An open issue is to what degree a further increase in processed blood volume is reasonable in terms of higher yields and safety. In 30 LVL performed in patients with hematologic malignancies, 6 total blood volumes were processed. LVL resulted in a higher CD34+ cell yield without a change in graft quality. Although a marked platelet decrease can be expected, LVL is safe and can be recommended as the standard procedure for patients who mobilize low numbers of CD34+ cells and when high number of CD34+ cells are required. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：139 / 147

页数：9

共 55 条

[11] Kinetics of standardized large volume leukapheresis (LVL) in patients do not show a recruitment phenomenon of peripheral blood progenitor cells (PBPC) [J].

Cassens, U ;

Momkvist, PH ;

Zuehlsdorf, M ;

Mohr, M ;

Kienast, J ;

Berdel, WE ;

Sibrowski, W .

BONE MARROW TRANSPLANTATION, 2001, 28 (01) :13-20

[12] Plerixafor for Stem Cell Mobilization in Patients with Non-Hodgkin's Lymphoma and Multiple Myeloma [J].

Choi, Hye-Yoon ;

Yong, Chul-Soon ;

Yoo, Bong Kyu .

ANNALS OF PHARMACOTHERAPY, 2010, 44 (01) :117-126

[13] Collection and recruitment of CD34+ cells during large-volume leukapheresis [J].

Cull, G ;

Ivey, J ;

Chase, P ;

Picciuto, R ;

Herrmann, R ;

Cannell, P .

JOURNAL OF HEMATOTHERAPY, 1997, 6 (04) :309-314

[14] Collection of more hematopoietic progenitor cells with large volume leukapheresis in patients with multiple myeloma [J].

Desikan, KR ;

Jagannath, S ;

Siegel, D ;

Nelson, J ;

Bracy, D ;

Barlogie, B ;

Tricot, G .

LEUKEMIA & LYMPHOMA, 1998, 28 (5-6) :501-508

[15]

Fabritiis P, 1999, BONE MARROW TRANSPL, V23, P1229

[16] A combination of granulocyte-colony-stimulating factor (G-CSF) and plerixafor mobilizes more primitive peripheral blood progenitor cells than G-CSF alone: results of a European phase II study [J].

Fruehauf, Stefan ;

Vedwijk, Marlon Romano ;

Seeger, Timon ;

Schubert, Mario ;

Laufs, Stephanie ;

Topaly, Julian ;

Wuchter, Patrick ;

Dillmann, Falk ;

Eckstein, Volker ;

Wenz, Frederik ;

Goldschmidt, Hartmut ;

Ho, Anthony Dick ;

Calandra, Gary .

CYTOTHERAPY, 2009, 11 (08) :992-1001

[17] PBPC collection techniques:: standard versus large volume leukapheresis (LVL) in donors and in patients [J].

Gasová, Z ;

Marinov, I ;

Vodvárková, S ;

Böhmová, M ;

Bhuyian-Ludvíková, Z .

TRANSFUSION AND APHERESIS SCIENCE, 2005, 32 (02) :167-176

[18] Differential mobilization of myeloma cells and normal hematopoietic stem cells in multiple myeloma after treatment with cyclophosphamide and granulocyte-macrophage colony-stimulating factor [J].

Gazitt, Y ;

Tian, EM ;

Barlogie, B ;

Reading, CL ;

Vesole, DH ;

Jagannath, S ;

Schnell, J ;

Hoffman, R ;

Tricot, G .

BLOOD, 1996, 87 (02) :805-811

[19] PURIFIED CD34(+) LIN(-) THY(+) STEM-CELLS DO NOT CONTAIN CLONAL MYELOMA CELLS [J].

GAZITT, Y ;

READING, CC ;

HOFFMAN, R ;

WICKREMA, A ;

VESOLE, DH ;

JAGANNATH, S ;

CONDINO, J ;

LEE, B ;

BARLOGIE, B ;

TRICOT, G .

BLOOD, 1995, 86 (01) :381-389

[20] Large-volume leukapheresis in pediatric patients: Processing more blood diminishes the apparent magnitude of intra-apheresis recruitment [J].

Gorlin, JB ;

Vamvakas, EC ;

Cooke, E ;

Galacki, D ;

Geha, R ;

Humphreys, D ;

Kent, P .

TRANSFUSION, 1996, 36 (10) :879-885

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