Large volume leukapheresis: Efficacy and safety of processing patient's total blood volume six times

被引：23

作者：

Bojanic, Ines ^{[1
]}

Dubravcic, Klara ^{[2
]}

Batinic, Drago ^{[2
]}

Cepulic, Branka Golubic ^{[1
]}

Mazic, Sanja ^{[1
]}

Hren, Darko ^{[3
]}

Nemet, Damir ^{[4
]}

Labar, Boris ^{[4
]}

机构：

[1] Univ Hosp Ctr Zagreb, Dept Transfus Med & Cellular Therapy, Zagreb 10000, Croatia

[2] Univ Hosp Ctr Zagreb, Dept Immunol, Zagreb 10000, Croatia

[3] Univ Split, Fac Philosophy, Zajceva Bb, Split, Croatia

[4] Univ Hosp Ctr Zagreb, Dept Internal Med, Zagreb 10000, Croatia

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2011年 / 44卷 / 02期

关键词：

STEM-CELL COLLECTION; COLONY-FORMING-UNITS; PROGENITOR CELLS; GRANULOCYTE-MACROPHAGE; MULTIPLE-MYELOMA; CROSSOVER TRIAL; CD34(+) CELLS; HEMATOPOIETIC PROGENITORS; PEDIATRIC-PATIENTS; APHERESIS;

D O I：

10.1016/j.transci.2011.01.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Large-volume leukapheresis (LVL) differs from standard leukapheresis by increased blood flow and an altered anticoagulation regimen. An open issue is to what degree a further increase in processed blood volume is reasonable in terms of higher yields and safety. In 30 LVL performed in patients with hematologic malignancies, 6 total blood volumes were processed. LVL resulted in a higher CD34+ cell yield without a change in graft quality. Although a marked platelet decrease can be expected, LVL is safe and can be recommended as the standard procedure for patients who mobilize low numbers of CD34+ cells and when high number of CD34+ cells are required. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：139 / 147

页数：9

共 55 条

[1] Intra-apheresis recruitment of blood progenitor cells in children [J].

Abe, T ;

Makimoto, A ;

Kawano, Y ;

Okamoto, Y ;

Kajiume, T ;

Nakagawa, R ;

Watanabe, H ;

Sato, J ;

Watanabe, T ;

Kuroda, Y ;

Takaue, Y .

TRANSFUSION, 1998, 38 (10) :944-950

[2] Large-volume leukapheresis yields more viable CD34+cells and colony-forming units than normal-volume leukapheresis, especially in patients who mobilize low numbers of CD34+cells [J].

Abrahamsen, JF ;

Stamnesfet, S ;

Liseth, K ;

Hervig, T ;

Bruserud, O .

TRANSFUSION, 2005, 45 (02) :248-253

[3] Long-Term Follow-Up of Autotransplantation Trials for Multiple Myeloma: Update of Protocols Conducted by the Intergroupe Francophone du Myelome, Southwest Oncology Group, and University of Arkansas for Medical Sciences [J].

Barlogie, Bart ;

Attal, Michel ;

Crowley, John ;

van Rhee, Frits ;

Szymonifka, Jackie ;

Moreau, Philippe ;

Durie, Brian G. M. ;

Harousseau, Jean-Luc .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (07) :1209-1214

[4] Preapheresis peripheral blood CD34+ mononuclear cell counts as predictors of progenitor cell yield [J].

Benjamin, RJ ;

Linsley, L ;

Fountain, D ;

Churchill, WH ;

Sieff, C ;

Cannon, ME ;

Uhl, L ;

Gaynes, L ;

Antin, JH ;

Wheeler, C .

TRANSFUSION, 1997, 37 (01) :79-85

[5] Comparison of processing four and five times the patients' blood volume during peripheral blood stem cell collection and analysis of CD34+38- and CD34+49d+ subsets during apheresis [J].

Bojko, P ;

Scharifi, M ;

Stössel, K ;

Seeber, S .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2002, 128 (01) :19-28

[6]

Bojko P, 1999, J CLIN APHERESIS, V14, P18, DOI 10.1002/(SICI)1098-1101(1999)14:1<18::AID-JCA4>3.3.CO

[7]

2-R

[8] Reduction of adverse citrate reactions during autologous large-volume PBPC apheresis by continuous infusion of calcium-gluconate [J].

Buchta, C ;

Macher, M ;

Bieglmayer, C ;

Höcker, P ;

Dettke, M .

TRANSFUSION, 2003, 43 (11) :1615-1621

[9] Factors affecting the efficacy of peripheral blood progenitor cells collections by large-volume leukaphereses with standardized processing volumes [J].

Cassens, U ;

Barth, IM ;

Baumann, C ;

Fischer, RJ ;

Kienast, J ;

Vormoor, J ;

Sibrowski, W .

TRANSFUSION, 2004, 44 (11) :1593-1602

[10]

Cassens U, 1999, TRANSFUSION MED, V9, P311

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