How Does Electroconvulsive Therapy Work? Theories on Its Mechanism

被引：111
作者：
Bolwig, Tom G. [1 ]
机构：
[1] Copenhagen Univ Hosp, Dept Psychiat, Copenhagen, Denmark
来源：
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE | 2011年 / 56卷 / 01期
关键词：
electroconvulsive therapy; theory; seizures; mechanism; neurogenesis; hypothalamus; hippocampus; melancholic depression; TRANSCRANIAL MAGNETIC STIMULATION; DEXAMETHASONE-SUPPRESSION TEST; NEUROPEPTIDE-Y NPY; HIPPOCAMPAL VOLUME; DEPRESSED-PATIENTS; SEIZURES INCREASE; SYNAPTIC PROTEINS; NEUROGENESIS; ECT; VASOPRESSIN;
D O I：
10.1177/070674371105600104
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
This article reviews 3 current theories of electroconvulsive therapy (ECT). One theory points to generalized seizures as essential for the therapeutic efficacy of ECT. Another theory highlights the normalization of neuroendocrine dysfunction in melancholic depression as a result of ECT. A third theory is based on recent findings of increased hippocampal neurogenesis and synaptogenesis in experimental animals given electroconvulsive seizures. Presently, the endocrine theory has the strongest foundation to explain the working mechanism of ECT.
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页码：13 / 18
页数：6
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