How Does Electroconvulsive Therapy Work? Theories on Its Mechanism

被引：108
作者：
Bolwig, Tom G. [1 ]
机构：
[1] Copenhagen Univ Hosp, Dept Psychiat, Copenhagen, Denmark
来源：
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE | 2011年 / 56卷 / 01期
关键词：
electroconvulsive therapy; theory; seizures; mechanism; neurogenesis; hypothalamus; hippocampus; melancholic depression; TRANSCRANIAL MAGNETIC STIMULATION; DEXAMETHASONE-SUPPRESSION TEST; NEUROPEPTIDE-Y NPY; HIPPOCAMPAL VOLUME; DEPRESSED-PATIENTS; SEIZURES INCREASE; SYNAPTIC PROTEINS; NEUROGENESIS; ECT; VASOPRESSIN;
D O I：
10.1177/070674371105600104
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
This article reviews 3 current theories of electroconvulsive therapy (ECT). One theory points to generalized seizures as essential for the therapeutic efficacy of ECT. Another theory highlights the normalization of neuroendocrine dysfunction in melancholic depression as a result of ECT. A third theory is based on recent findings of increased hippocampal neurogenesis and synaptogenesis in experimental animals given electroconvulsive seizures. Presently, the endocrine theory has the strongest foundation to explain the working mechanism of ECT.
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页码：13 / 18
页数：6
相关论文
共 57 条
  • [1] ELECTROCONVULSIVE THERAPY AND DIENCEPHALON - PRELIMINARY REPORT
    ABRAMS, R
    TAYLOR, MA
    [J]. COMPREHENSIVE PSYCHIATRY, 1974, 15 (03) : 233 - 236
  • [2] DIENCEPHALIC STIMULATION AND EFFECTS OF ECT IN ENDOGENOUS-DEPRESSION
    ABRAMS, R
    TAYLOR, MA
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 1976, 129 (NOV) : 482 - 485
  • [3] ABRAMS R, 1991, CONVULSIVE THER, V7, P213
  • [4] ALLEN JP, 1974, AM J PSYCHIAT, V131, P1225
  • [5] Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways
    Altar, CA
    Laeng, P
    Jurata, LW
    Brockman, JA
    Lemire, A
    Bullard, J
    Bukhman, YV
    Young, TA
    Charles, V
    Palfreyman, MG
    [J]. JOURNAL OF NEUROSCIENCE, 2004, 24 (11) : 2667 - 2677
  • [6] [Anonymous], ARCH NEUROL PSYCHIAT
  • [7] Two-Year Outcome of Vagus Nerve Stimulation in Treatment-Resistant Depression
    Bajbouj, Malek
    Merkl, Angela
    Schlaepfer, Thomas E.
    Frick, Caroline
    Zobel, Astrid
    Maier, Wolfgang
    O'Keane, Veronica
    Corcoran, Ciaran
    Adolfsson, Rolf
    Trimble, Michael
    Rau, Harald
    Hoff, Hans-Joachim
    Padberg, Frank
    Mueller-Siecheneder, Florian
    Audenaert, Kurt
    van den Abbeele, Dirk
    Matthews, Keith
    Christmas, David
    Eljamel, Sam
    Heuser, Isabella
    [J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2010, 30 (03) : 273 - 281
  • [8] Electroconvulsive therapy in melancholia: the role of hippocampal neurogenesis
    Bolwig, T. G.
    Madsen, T. M.
    [J]. ACTA PSYCHIATRICA SCANDINAVICA, 2007, 115 : 130 - 135
  • [9] SYNAPTIC PROTEINS AFTER ELECTROCONVULSIVE STIMULATION - REVERSIBILITY AND REGIONAL DIFFERENCES IN THE BRAIN
    BOLWIG, TG
    JORGENSEN, OS
    [J]. ACTA PSYCHIATRICA SCANDINAVICA, 1980, 62 (05) : 486 - 493
  • [10] Carney S, 2003, LANCET, V361, P799
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