Cyanides-Free Cyanation of Aryl Halides using Formamide

被引：78
|
作者：
Sawant, Dinesh N. [1 ]
Wagh, Yogesh S. [1 ]
Tambade, Pawan J. [1 ]
Bhatte, Kushal D. [1 ]
Bhanage, Bhalchandra M. [1 ]
机构：
[1] Deemed Univ, Inst Chem Technol, Dept Chem, Bombay 400019, Maharashtra, India
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 05期
关键词：
aryl halides; C-C coupling; cyanation; formamide; nitriles; palladium; PALLADIUM-CATALYZED CYANATION; MONOXIDE-FREE AMINOCARBONYLATION; POTASSIUM HEXACYANOFERRATE(II); NUCLEOPHILIC DISPLACEMENT; TRANSITION-METAL; BROMIDES; EFFICIENT; SYSTEM; CONVENIENT; COMPLEXES;
D O I：
10.1002/adsc.201000807
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A novel method for cyanation of aryl halides using formamide as a non-toxic cyanide source is reported. It is a single-step, solvent-free method wherein formamide itself acts as solvent as well as source of cyanide in the presence of phosphorus oxychloride and palladium acetate/xantphos catalyst. Aryl iodides as well as aryl bromides provided moderate to excellent yields of up to 93%.
引用
收藏
页码：781 / 787
页数：7
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