Endocrine and chronobiological effects of fasting in women

被引:21
作者
Berga, SL
Loucks, TL
Cameron, JL
机构
[1] Univ Pittsburgh, Sch Med, Magee Womens Hosp, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15213 USA
[3] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA
[4] Univ Pittsburgh, Sch Med, Dept Neurosci, Pittsburgh, PA 15213 USA
[5] Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, Pittsburgh, PA 15213 USA
关键词
fasting; ovulation; melatonin;
D O I
10.1016/S0015-0282(01)01686-7
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To determine whether fasting in women would suppress GnRH/LH drive in a high-versus low-gonadal steroid milieu. Design: Case-control study. Setting: Academic clinical research center. Patient(s): Eleven eumenorrheic women and eleven women taking combined oral contraceptives. Intervention(s): Seven of the eleven women in each group underwent an acute 72-hour fast. Blood samples were obtained at 15-minute intervals for 24 hours before the fast and during the last 24 hours of fasting. Main Outcome Measure(s): Twenty-four-hour profiles of LH, cortisol, and melatonin were assessed. Ovarian activity was tracked with estradiol and progesterone levels, and metabolic responses were gauged by measuring thyroid hormone and beta -hydroxy-butyric acid levels. Result(s): Fasting increased beta -hydroxy-butyric acid and reduced free thyronine. Fasting in the midfollicular phase had no effect on LH pulsatility or on FSH, estradiol, or subsequent luteal-phase progesterone levels. However, fasting elevated cortisol and resulted in a phase advance in melatonin secretion of 81 minutes in both the midfollicular and luteal phases. Conclusion(s): Fasting in women elicited expected metabolic responses and apparently advanced the central circadian clock without compromising reproductive function. (Fertil Steril(R) 2001;75:926-32. (C)2001 by American Society for Reproductive Medicine.).
引用
收藏
页码:926 / 932
页数:7
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