Three-Dimensional Graphene Composite Macroscopic Structures for Capture of Cancer Cells

被引：83

作者：

Yin, Shengyan ^{[1
]}

Wu, Yun-Long ^{[1
,2
]}

Hu, Benhui ^{[1
]}

Wang, Yu ^{[1
]}

Cai, Pingqiang ^{[1
]}

Tan, Chek Kun ^{[3
]}

Qi, Dianpeng ^{[1
]}

Zheng, Liyan ^{[1
]}

Leow, Wan Ru ^{[1
]}

Tan, Nguan Soon ^{[3
,4
]}

Wang, Shutao ^{[5
]}

Chen, Xiaodong ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore

[2] Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361102, Fujian, Peoples R China

[3] Nanyang Technol Univ, Sch Biol Sci, Singapore 637551, Singapore

[4] ASTAR, IMCB, Singapore 138673, Singapore

[5] Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China

来源：

ADVANCED MATERIALS INTERFACES | 2014年 / 1卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

CIRCULATING TUMOR-CELLS; EFFICIENT CAPTURE; NANOSTRUCTURED SURFACES; PHOTOTHERMAL THERAPY; SILICON NANOWIRES; PERIPHERAL-BLOOD; OXIDE; RELEASE; SIZE; METASTASIS;

D O I：

10.1002/admi.201300043

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A hierarchical nanostructured 3D platform is reported that combines microporosity with a nanostructure for selective capture of cancer cells. The microporosity allows red blood cells to travel through, while the anti-EpCAM modified nanostructure captures circulating tumor cells. These systems allow for considerable increase in the contact frequency between target cells and the substrate, thus enhancing the cancer cell filtration and isolation efficiency. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

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