Measuring and estimating insulin resistance in clinical and research settings

被引：110

作者：

Gastaldelli, Amalia ^{[1
]}

机构：

[1] Natl Res Council CNR, Inst Clin Physiol IFC, Pisa, Italy

来源：

OBESITY | 2022年 / 30卷 / 08期

基金：

欧盟地平线“2020”;

关键词：

HYPERINSULINEMIC-EUGLYCEMIC CLAMP; HOMEOSTASIS MODEL ASSESSMENT; FATTY LIVER-DISEASE; BETA-CELL FUNCTION; GLUCOSE-TOLERANCE; ADIPOSE-TISSUE; MINIMAL-MODEL; SENSITIVITY MEASURES; NONDIABETIC SUBJECTS; SURROGATE MEASURES;

D O I：

10.1002/oby.23503

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The article discusses how to measure insulin resistance in muscle, liver, and adipose tissue in human participants. The most frequently used methodologies to evaluate insulin resistance are described in detail starting from the gold standard, that is, the euglycemic hyperinsulinemic clamp, to the intravenous glucose tolerance test, surrogate indices based on fasting measurements, or dynamic tests (such as oral glucose or mixed meal tolerance tests). The accuracy, precision, and reproducibility of the tests as well as cutoff values are reported.

引用

页码：1549 / 1563

页数：15

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